中国药物评价2024，Vol.41Issue(3)：185-191,7.
核黄素磷酸钠中核黄素含量测定的测量不确定度评定
Evaluation of Measurement Uncertainty on Determination of Riboflavin in Riboflavin Sodium Phosphate
梁爱仙 1陈颜清 1杨雅贤 1庞发根 1梁智渊 1殷果 1王晓炜1
作者信息
- 1. 深圳药品质量标准研究重点实验室,深圳市药品检验研究院,广东深圳 518057
- 折叠
摘要
Abstract
Objective:To evaluate the measurement uncertainty on determination of riboflavin in riboflavin sodium phosphate,and the factors that affect the uncertainty by high performance liquid chromatography(HPLC).Methods:A mathematical model for the determi-nation was established,the factors affecting the uncertainty was found,and the related uncertainty components were evaluated.The synthet-ic uncertainty and the expanded uncertainty of the determination by HPLC were obtained after analyzing the relative standard uncertainty of each component.Results:The content of riboflavin in riboflavin sodium phosphate was 2.90％,the synthesis uncertainty in the determi-nation was 0.011％,the measurement result was expressed as(2.90±0.011)％.Conclusion:The method of the uncertainty evalua-tion for the determination of riboflavin in riboflavin sodium phosphate by HPLC method is established.The main sources of uncertainty are analyzed.This research provides a reliable theoretical basis for effectively controlling the accuracy of the determination method of sodium ion content.关键词
不确定度评价/核黄素/核黄素磷酸钠/PHLC法Key words
Uncertainty evaluation/Riboflavin/Riboflavin sodium phosphate/High performance liquid chromatography(HPLC)分类
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梁爱仙,陈颜清,杨雅贤,庞发根,梁智渊,殷果,王晓炜..核黄素磷酸钠中核黄素含量测定的测量不确定度评定[J].中国药物评价,2024,41(3):185-191,7.
