中国药物评价2024，Vol.41Issue(3)：233-237,5.
基于网络药理学研究珍珠通络丸对帕金森病的作用机制
The Mechanism of Zhenzhu Tongluo Pill in the Treatment of Parkinson's Disease based on Network Pharmacology
摘要
Abstract
Objective:To predict the molecular mechanism of Mongolian medicine Zhenzhu Tongluo Pill in treating Parkinson's dis-ease(PD)through network pharmacology and molecular docking.Methods:The Main active ingredients and potential targets of action of Zhenzhu Tongluo Pill were screened through TCMSP database.The targets of Parkinson's disease were obtained through OMIM,Gene-Cards,and TTD websites.Venny diagrams were drawn using Venny 2.1.0 website and protein-protein interaction(PPI)network diagrams were obtained through STRING website.GO function analysis and KEGG enrichment analysis was performed using the microbiome web-site.Results:According to the screening criteria,112 main active ingredients were screened in Zhenzhu Tongluo Pill,involving 199 po-tential targets for treating PD.The KEGG enrichment pathway showed that Zhenzhu Tongluo Pill treated PD mainly through lipid and ath-erosclerosis,tumor necrosis factor,IL-17,PI3K-AKT,and cell apoptosis signal pathways.The molecular docking results showed that ef-fective compounds such as quercetin,kaempferol,meltein,β-sitosterol and baicalein could all bind well with core proteins such as AKT1,JUN,TNF,PRKACA.Conclusion:The mechanism of Zhenzhu Tongluo Pill on treating PD may be related to regulating the activity of tar-get proteins,such as AKT1,JUN,TNF,PRKACA,which will provide a basis for studying the active component and molecular mecha-nism of Zhenzhu Tongluo Pill in treatment for PD.关键词
珍珠通络丸/帕金森病/网络药理学/分子对接/作用机制Key words
Zhenzhu Tongluo pill/Parkinson's disease/Network pharmacology/Molecular docking/Mechanism of action分类
医药卫生引用本文复制引用
张雅蓓,孙嘉骏,赵艳青,华志鹏,白海花,贾小娥,杨志甫..基于网络药理学研究珍珠通络丸对帕金森病的作用机制[J].中国药物评价,2024,41(3):233-237,5.基金项目
国家自然科学基金项目(81901918) （81901918）
内蒙古自然科学基金(2021MS08053) （2021MS08053）
2022年内蒙古人才开发基金 （）
包头医学院青年科技人才发展计划(BYJJ-DXK-2022042) （BYJJ-DXK-2022042）
内蒙古自治区卫生健康科技计划项目(202201422) （202201422）
中国科学院2019年度西部青年学者 （）
包头医学院创新团队(bycxtd-04) （bycxtd-04）
自治区高等学校科学研究项目(NJZY23093) （NJZY23093）
