微波消融联合无水乙醇消融治疗囊性甲状腺结节患者的临床研究OA
Clinical Study of Microwave Ablation Combined with Anhydrous Ethanol Ablation in the Treatment of Patients with Cystic Thyroid Nodules
目的:研究微波消融(MWA)联合无水乙醇消融(EA)治疗囊性甲状腺结节对患者临床症状、结节体积及甲状腺功能的影响.方法:选取 2021 年 1 月—2022 年 6 月赣州市赣县区人民医院收治的囊性甲状腺结节患者 81 例.采用随机数字表法分为对照组 40 例和观察组 41 例.对照组采用超声引导下MWA治疗,观察组在对照组基础上联合EA治疗.比较两组不同时间段结节体积及体积缩小率、临床效果、甲状腺功能[三碘甲状原氨酸(T3)、甲状腺素(T4)、游离三碘甲状原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)]水平及术后并发症发生率.结果:术前,两组结节体积比较,差异无统计学意义(P>0.05);术后 1、3、6 及 12 个月观察组结节体积均小于对照组,且结节缩小率均高于对照组,差异均有统计学意义(P<0.05).观察组总有效率(92.68%)高于对照组(72.50%),差异有统计学意义(P<0.05).术前及术后 12 个月,两组甲状腺功能T3、T4、FT3、FT4 及TSH水平比较,差异均无统计学意义(P>0.05).观察组术后并发症发生率(7.32%)低于对照组(25.00%),差异有统计学意义(P<0.05).结论:MWA联合EA治疗囊性甲状腺结节患者可以缩小甲状腺结节体积,提升临床效果,从而有效降低术后并发症发生,且对甲状腺功能无明显影响.
Objective:To investigate the effect of microwave ablation(MWA)combined with anhydrous ethanol ablation(EA)on clinical symptoms,nodule volume and thyroid function in patients with cystic thyroid nodules.Method:A total of 81 patients with cystic thyroid nodules who were admitted to Ganxian People's Hospital,Ganzhou City from January 2021 to June 2022 were selected,they were divided into a control group(40 cases)and an observation group(41 cases)by random number table method.The control group was treated with ultrasound-guided MWA,and the observation group was treated combined with EA on the basis of the control group.The nodule volume and volume reduction rates at different time,clinical efficacy,thyroid function[triiodothyronine(T3),thyroxine(T4),free triiodothyronine(FT3),free thyronine(FT4)and thyroid-stimulating hormone(TSH)]and incidence of postoperative complications were compared between groups.Result:There was no statistically significant difference in preoperative nodule volume between the two groups(P>0.05);at 1,3,6 and 12 months after surgery,nodule volume in the observation group were smaller than those in the control group,and the nodule reduction rate were higher than those in the control group,the differences were statistically significant(P<0.05).The total effective rate in the observation group(92.68% )was significantly higher than that in the control group(72.50% ),the difference was statistically significant(P<0.05).Before surgery and at 12 months after surgery,there were no statistically significant differences in the levels of T3,T4,FT3,FT4 and TSH in the two groups(P>0.05).The incidence of postoperative complications in the observation group(7.32% )was significantly lower than that in the control group(25.00% ),the difference was statistically significant(P<0.05).Conclusion:MWA combined with EA treatment can reduce the volume of thyroid nodules,improve clinical efficacy,and effectively reduce the incidence of postoperative complications in patients with cystic thyroid nodules,without significant impact on thyroid function.
易正禧;吴应金;刘远红
赣州市赣县区人民医院普外科 江西 赣州 341100
微波消融无水乙醇消融囊性甲状腺结节临床症状结节体积甲状腺功能
Microwave ablationAnhydrous ethanol ablationCystic thyroid noduleClinical symptomNodule volumeThyroid function
《中国医学创新》 2024 (019)
80-84 / 5
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