中国医学创新2024，Vol.21Issue(20)：145-149,5.DOI:10.3969/j.issn.1674-4985.2024.20.034
来曲唑联合促性腺激素治疗PCOS不孕的效果
Effects of Letrozole Combined with Gonadotropin on Infertility Patients with PCOS
摘要
Abstract
Objective:To investigate the effects of Letrozole combined with gonadotropin on endometrial thickness,luteinizing hormone(LH),ovulation and pregnancy in infertility patients with polycystic ovary syndrome(PCOS).Method:A total of 200 PCOS infertility patients admitted to the Fujian University of Traditional Chinese Medicine Affiliated Third People's Hospital from January to December 2022 were selected as the study objects,and they were divided into observation group and control group by random number table method,with 100 cases in each group.The control group was treated with gonadotropin alone,while the observation group was treated with Letrozole combined with gonadotropin.Endometrial thickness,LH,ovulation and pregnancy were compared between the two groups.Result:After treatment,endometrial thickness in both groups were higher than those before treatment,LH were lower than those before treatment,and endometrial thickness in observation group was higher than that in control group,LH was lower than that in control group,the differences were statistically significant(P<0.05).The follicle growth time of the observation group was shorter than that of the control group,and the number of ovulation and dominant follicles were higher than those of the control group,the differences were statistically significant(P<0.05).After 1 year of follow-up,the pregnancy rate of the observation group was higher than that of the control group,and the multiple pregnancy rate and abortion rate were lower than those of the control group,the differences were statisticaly significant(P<0.05).Conclusion:Letrozole combined with gonadotropin in the treatment of PCOS infertility can increase endometrial thickness,decrease LH level,promote ovulation and increase pregnancy rate.关键词
多囊卵巢综合征/不孕症/来曲唑/促性腺激素/子宫内膜厚度/黄体生成素/妊娠率Key words
Polycystic ovary syndrome/Infertility/Letrozole/Gonadotropin/Endometrial thickness/Luteinizing hormone/Pregnancy rate引用本文复制引用
徐滢,连熙娜,蒋鑫芳,王虹,王琳琳,陈燕花,林菁,胡国秀..来曲唑联合促性腺激素治疗PCOS不孕的效果[J].中国医学创新,2024,21(20):145-149,5.基金项目
福建省自然科学基金项目(2023J01883) （2023J01883）
