内科2024，Vol.19Issue(3)：257-261,5.
手足口病患儿胃生长激素释放素水平与TLR4信号通路的相关性研究
Correlation between the ghrelin level and TLR4 signal pathway in children with hand,foot,and mouth disease
摘要
Abstract
Objective To analyze the correlation between the ghrelin level and Toll-like receptor(TLR)4 signal pathway in children with hand,foot,and mouth disease(HFMD),and to explore the mechanism of ghrelin in the inflammatory immune response of HFMD.Methods The clinical data of 100 children with HFMD were retrospectively analyzed,they were divided into a mild group(n=65)or a severe group(n=35)according to their severity,and 100 healthy children were selected as the control group(n=100).The ghrelin level,as well as the positive expression rate and the mean fluorescence intensity(MFI)of TLR4,was compared between the three groups,and the correlations of the ghrelin level with the positive expression rate and the MFI of TLR4 were explored by linear correlation analysis.Results There were statistically significant differences in the ghrelin level,positive expression rate of TLR4,and MFI of TLR4 between the three groups(all P＜0.05).The ghrelin levels of the control group,the mild group,and the severe group decreased successively,while the positive expression rate and MFI of TLR4 of the severe group,the mild group,and the control group decreased successively(all P＜0.05).The linear correlation analyses results showed that the ghrelin level was negatively correlated with the positive expression rate of TLR4(r=-0.729)and the MFI of TLR4(r=-0.697)in children with HFMD(all P＜0.05).Conclusion In children with HFMD,the ghrelin level decreased,the positive expression rate and the MFI of TLR4 increased,and the ghrelin level was negatively correlated with the positive expression rate and the MFI of TLR4.Ghrelin may play a protective role in the inflammatory immune response in the pathogenesis of HFMD,with an inhibition effect on the TLR4 signal pathway.关键词
手足口病/胃生长激素释放素/Toll样受体4/平均荧光强度Key words
Hand,foot,and mouth disease/Ghrelin/Toll-like receptor 4/Mean fluorescence intensity分类
医药卫生引用本文复制引用
冯海鹰,陈裕佳,黄波,梁庆,廖素雯,梁莹,廖必才..手足口病患儿胃生长激素释放素水平与TLR4信号通路的相关性研究[J].内科,2024,19(3):257-261,5.基金项目
广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z2015103) （Z2015103）
