中国药业2024，Vol.33Issue(14)：80-83,4.DOI:10.3969/j.issn.1006-4931.2024.14.019
心脉舒一号口服液质量标准提升研究
Improvement of Quality Standard of Xinmaishu Yihao Oral Liquid
摘要
Abstract
Objective To improve the quality standard of Xinmaishu Yihao Oral Liquid.Methods Ophiopogonis Radix and Schisandrae Chinensis Fructus in the preparation were qualitatively identified by the thin layer chromatography(TLC)method.With rutin and D(+)-anhydrous glucose as the reference,the contents of total flavonoids and total polysaccharides in the preparation were determined by the ultraviolet-visible spectroscopy(UV-Vis)at wavelengths of 504,490 nm,respectively.Results The TLC chromatograms of Ophiopogonis Radix and Schisandrae Chinensis Fructus showed clear spots,good resolution,and there was no interference from the negative reference.The linear ranges of rutin and D(+)-anhydrous glucose were 0.016 7-0.058 5 mg/mL(R2=0.999 3,n=6),0.002 7-0.016 2 mg/mL(R2=0.987 9,n=6)respectively.The RSDs of precision,stability and repeatability tests were all lower than 1.0% .The average recovery rates of total flavonoids and total polysaccharides were 99.85% and 99.80%,with the RSDs of 0.04% and 0.22% (n=6)respectively.The average contents of total flavonoids and total polysaccharides in 19 batches of preparation were 0.695,22.30 mg/mL respectively.Conclusion This method is easy,sensitive,precise,stable and repeatable,which can be used for the quality control of Xinmaishu Yihao Oral Liquid.关键词
心脉舒一号口服液/薄层色谱法/紫外-可见分光光度法/总黄酮/总多糖/质量控制Key words
Xinmaishu Yihao Oral Liquid/TLC/UV-Vis/total flavonoids/total polysaccharides/quality control分类
医药卫生引用本文复制引用
唐勇琛,张洪平,毛桂福,樊玲凤,杨玉竹,张亚洲..心脉舒一号口服液质量标准提升研究[J].中国药业,2024,33(14):80-83,4.基金项目
广西壮族自治区柳州市科技计划项目[2020NBAA0807]. （）
