电感耦合等离子体质谱法测定富马酸伏诺拉生片及其原料药中7种元素杂质含量OACSTPCD
Determination of Seven Elemental Impurities in Vonoprazan Fumarate Tablets and Its Raw Materials by Inductively Coupled Plasma-Mass Spectrometry
目的 建立测定富马酸伏诺拉生片及其原料药中 7 种元素杂质含量的电感耦合等离子体质谱法(ICP-MS)法.方法 等离子功率为 1 550 W,等离子体气为氩气,流速为 14 L/min,载气为氩气,流速为 4.9 mL/min,蠕动泵转速为 40 r/min,采用动能歧视(KED)测定模式,全定量分析获取模式.结果 砷、镉、汞、铅、钴、镍、钒质量浓度分别在 0～30 ng/mL、0～12 ng/mL、0～60 ng/mL、0～12 ng/mL、0…查看全部>>
Objective To establish an inductively coupled plasma-mass spectrometry(ICP-MS)method for the determination of seven elemental impurities in Vonoprazan Fumarate Tablets and its raw materials.Methods The plasma power was 1 550 W,the plasma gas was argon with a flow rate of 14 L/min,the carrier gas was argon with a flow rate of 4.9 mL/min,the rotation rate of peristaltic pump was 40 r/min,the kinetic energy discrimination(KED)determination mode and full-quantit…查看全部>>
龚翠云;朱婧;王玲兰;刘秀;彭国卿
株洲千金药业股份有限公司,湖南 株洲 412000株洲千金药业股份有限公司,湖南 株洲 412000株洲千金药业股份有限公司,湖南 株洲 412000株洲千金药业股份有限公司,湖南 株洲 412000株洲千金药业股份有限公司,湖南 株洲 412000
药学
电感耦合等离子体质谱法富马酸伏诺拉生片原料药元素杂质含量测定
inductively coupled plasma-mass spectrometryVonoprazan Fumarate Tabletsraw materialelemental impuritycontent determination
《中国药业》 2024 (14)
91-94,4
湖南省自然科学基金[2022JJ80049].
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