中国医药科学2024，Vol.14Issue(12)：26-29,34,5.DOI:10.20116/j.issn2095-0616.2024.12.06
巨噬细胞自噬调节急性肺损伤/急性呼吸窘迫综合征的研究进展
Research progress of macrophage autophagy in regulating acute lung injury/acute respiratory distress syndrome
摘要
Abstract
Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS)is a critical clinical syndrome with high morbidity and mortality.Macrophages,as an important part of innate immunity,play a key role in the regulation of inflammatory reaction and immune system homeostasis.Autophagy is a self-protection mechanism initiated under stress conditions.Macrophage autophagy activation affects ALI/ARDS processes through a variety of pathways,including regulation of macrophage polarization,regulation of macrophage phagocytosis,inhibition of NOD-like receptor family domain 3(NLRP3)inflammasome formation,regulation of endoplasmic reticulum stress(ERS),and regulation of mammalian target of rapamycin(mTOR)signaling.Macrophage autophagy activation provides a new therapeutic target for alleviating ALI/ARDS.关键词
巨噬细胞/自噬/急性呼吸窘迫综合征/急性肺损伤Key words
Macrophage/Autophagy/Acute respiratory distress syndrome/Acute lung injury分类
医药卫生引用本文复制引用
宋雨彤,王晓芝..巨噬细胞自噬调节急性肺损伤/急性呼吸窘迫综合征的研究进展[J].中国医药科学,2024,14(12):26-29,34,5.基金项目
山东省自然科学基金(ZR2022MH012). （ZR2022MH012）
