中国医药科学2024，Vol.14Issue(12)：55-58,4.DOI:10.20116/j.issn2095-0616.2024.12.13
丁苯酞在急性缺血性脑卒中早期神经功能恶化中的效果观察
Observation on the effect of butylphthalide in the early neurological deterioration of acute ischemic stroke
摘要
Abstract
Objective To investigate the application value of butylphthalide in the early neurological deterioration(END)of acute ischemic stroke.Methods A total of 112 patients in the END of acute ischemic stroke treated in Lianjiang People's Hospital from September 2021 to May 2023 were selected as the research object.The patients were divided into the observation group and the control group according to the random number table method,with 56 patients in each group.The control group was treated with atorvastatin tablets+aspirin enteric-coated tablets+clopidogrel bisulfate tablets,while the observation group was treated with butylphthalide on the basis of the control group.The therapeutic efficacy,serum cytokines,coagulation function indices and incidence of adverse reactions were compared between the two groups.Results The efficacy of the observation group was significantly better than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the concentrations of hypersensitive C-reactive protein,interleukin-6,neurofilament light protein and D-dimer in the two groups were lower than those before treatment,and the observation group was lower than that of the control group.The partially activated prothrombin time in the two groups was longer than that before treatment,and the observation group was longer than that of the control group,and the difference was statistically significant(P＜0.05).Comparison of the total incidence of adverse reactions between the two groups,the difference was not statistically significant(P＞0.05).Conclusion Butylphthalide in the treatment in the END of acute ischemic stroke can obviously improve the therapeutic efficacy,reduce the level of serum cytokines and improve the indices of coagulation function,without increasing the incidence of adverse reactions.关键词
丁苯酞/急性缺血性脑卒中/早期神经功能恶化/疗效/血清细胞因子/凝血功能/不良反应Key words
Butylphthalide/Acute ischemic stroke/Early neurological deterioration/Therapeutic efficacy/Serum cytokines/Coagulation function/Adverse reactions分类
医药卫生引用本文复制引用
黄勇,肖远流,王大明,杨景丽..丁苯酞在急性缺血性脑卒中早期神经功能恶化中的效果观察[J].中国医药科学,2024,14(12):55-58,4.基金项目
广东省湛江市非资助科技攻关计划项目(2021B01247). （2021B01247）
