中国肿瘤生物治疗杂志2024，Vol.31Issue(7)：647-654,8.DOI:10.3872/j.issn.1007-385x.2024.07.001
CAR-T细胞体内外扩增方法的优化策略
Optimization strategies for the amplification of CAR-T cells in vitro and in vivo
摘要
Abstract
Chimeric antigen receptor gene-modified T(CAR-T)cell immunotherapy is considered as one of the most promising tumor treatments.The number of effector CAR-T cells is a key factor in determining the therapeutic effect of CAR-T cell therapy.The expansion of CAR-T cells in vitro is time and energy-consuming.After transfusion,it's difficult for CAR-T cells to infiltrate into solid tumors,resulting in a significant decrease in the number of CAR-T cells that can effectively inhibit solid tumors.Currently,the amplification of CAR-T cells has problems in enhancing amplification specificity and treatment safety,which hinders the clinical transformation of CAR-T cell therapy.In recent years,achievements in new immunity agonist and their downstream signals have provided more options for CAR-T amplification,and the novel administration methods of immunity agonist have further improved the safety of CAR-T amplification in vivo.This review analyzes the current challenges in CAR-T cell amplification,and systematically expounds the new strategies of CAR-T cell amplification in vitro and in vivo in recent years,providing new thoughts for the efficacy and capacity optimization of CAR-T cell therapy.关键词
肿瘤/实体瘤/免疫治疗/CAR-T细胞疗法/特异性扩增Key words
tumor/solid tumor/immunotherapy/chimeric antigen receptor gene-modified T(CAR-T)cell therapy/specific amplification分类
基础医学引用本文复制引用
潘心怡,任政乾,王欣玥,王婷婷..CAR-T细胞体内外扩增方法的优化策略[J].中国肿瘤生物治疗杂志,2024,31(7):647-654,8.基金项目
中国博士后科学基金面上资助项目(No.2023M741629) （No.2023M741629）
国家自然科学基金面上项目(No.82273011,No.82072648) （No.82273011,No.82072648）
