中国中西医结合影像学杂志2024，Vol.22Issue(4)：385-389,5.DOI:10.3969/j.issn.1672-0512.2024.04.004
基于PET/CT不同勾画方法测量非小细胞肺癌原发灶代谢体积的差异性研究
Study of different delineating methods based on PET/CT for measurement of metabolic parameters in primary tumor of non-small cell lung cancer
摘要
Abstract
Objective:To evaluate the impact and repeatability of different PET/CT-based delineating methods for the measurement of metabolic parameters in primary tumor of non-small cell lung cancer(NSCLC).Methods:The data of 79 NSCLC patients who underwent 18F-FDG PET/CT examination were retrospectively analyzed.Maximum standardized uptake value(SUVmax)was measured.The metabolic tumor volume(MTV)and total lesion glycolysis(TLG)were calculated by three methods,the adaptive interative algorithm(AIA)method,the absolute threshold method(2.5,3,4),and the relative threshold method(40%,50%).The differences of metabolic parameters measured by different delineating methods were compared.The interobserver consistency on metabolic parameters were analyzed.Results:MTV was statistically different of different delineating methods(χ2=14.759,P=0.011),while TLG was not(χ2=3.013,P=0.698).For the absolute threshold method and the relative threshold method,the higher the threshold value,the smaller the values of MTV and TLG,and MTV and TLG measured by the relative threshold method were smaller.The repeatability was high for SUVmax,MTV and TLG using three different methods,and the interobserver consistency was high(all ICC>0.99).The relative threshold method(40%)had the highest percentage of without manual adjustment of 18.32%and the highest accuracy of 91.14%,with a significant difference(χ2=11.748,P=0.038).Conclusions:MTV and TLG have the high repeatability from different delineating methods,while MTV are different.The relative threshold method(40%)has the highest percentage of without manual adjustment and the highest accuracy,and is recommended for clinical use.关键词
癌,非小细胞肺/正电子发射断层成像/体层摄影术,X线计算机/勾画/重复性/代谢参数Key words
Carcinoma,non-small-cell lung/Positron emission tomography/Tomography,X-ray computed/Outline/Reproducibility/Metabolic parameters引用本文复制引用
朱俊辉,李思叶,黄子康,王静,周伟,陈薏帆,朱玉春..基于PET/CT不同勾画方法测量非小细胞肺癌原发灶代谢体积的差异性研究[J].中国中西医结合影像学杂志,2024,22(4):385-389,5.基金项目
江苏大学2023年度医教协同创新基金一般项目(JDYY2023060) （JDYY2023060）
昆山市第一人民医院2022年度广仁基金科研课题(临床研究专项)重点项目(KRY-YN2022001) （临床研究专项）
2023年昆山市级科技专项(社会发展)指导性项目(KSZ2311). （社会发展）
