中国中西医结合影像学杂志2024，Vol.22Issue(4)：424-429,6.DOI:10.3969/j.issn.1672-0512.2024.04.011
基于全病变MRI动态增强扫描直方图分析对小乳腺癌腋窝淋巴结转移的预测价值
Predictive value of whole-volume dynamic contrast-enhanced MRI histogram analysis to axillary lymph node metastasis of small breast cancer
摘要
Abstract
Objective:To predict axillary lymph node(ALN)metastasis of small breast cancer with whole-volume dynamic contrast-enhanced MRI(DCE-MRI)histogram analysis.Methods:The clinicopathological data of 93 patients with small breast cancer were retrospectively analyzed,of which 30 cases had ALN metastasis(the metastasis group)and 63 cases had no metastasis(the non-metastasis group).All patients underwent MRI examination before operation or further treatment.Fire Voxel software was used to outline ROI and histogram analysis was performed,and the histogram parameters of the two groups were compared by t test or Mann-Whitney U test.Pearson and Spearman correlation analysis were used to analyze the correlation between ALN metastasis and histogram parameters.Logistic regression was used to obtain the statistically different parameters between the two groups to develop the combined model.The ROC curve was used to analyze the diagnostic efficiency of histogram parameters for ALN metastasis.Results:Age and menopausal state were associated with ALN metastasis(both P<0.05).The histogram parameters,the minimum value,5th percentile,coefficient of variation and volume had significant correlations with ALN metastasis(all P<0.05).Among the histogram parameters,volume had the highest AUC of 0.729 in predicting ALN metastasis,and the best cut-off value was 1.765.The combination model of the minimum value,5th percentile,coefficient of variation,volume and age had the highest AUC of 0.780.Conclusions:Histogram analysis based on whole lesion DCE-MRI can be used to predict ALN metastasis of small breast cancer,and the combination of the minimum value,5th percentile,coefficient of variation and volume may be useful index for distinguishing ALN status.关键词
小乳腺癌/磁共振成像/动态增强扫描/直方图分析/腋窝淋巴结转移Key words
Small breast cancer/Magnetic resonance imaging/Dynamic contrast enhance/Histogram analysis/Axillary lymph node metastasis引用本文复制引用
马芹芹,卢星如,李芷凡,刘春翠,冯雯,雷军强..基于全病变MRI动态增强扫描直方图分析对小乳腺癌腋窝淋巴结转移的预测价值[J].中国中西医结合影像学杂志,2024,22(4):424-429,6.基金项目
甘肃省重点人才项目资助(甘组通字[2023]20号) （甘组通字[2023]20号）
甘肃省自然科学基金(21JR1RA079) （21JR1RA079）
甘肃省教育科技创新基金项目资助(2022B-025). （2022B-025）
