中国中西医结合影像学杂志2024，Vol.22Issue(4)：430-433,4.DOI:10.3969/j.issn.1672-0512.2024.04.012
非小细胞肺癌CT动态增强扫描定量参数与病理类型及靶向治疗远期预后的关系分析
Relationship between quantitative parameters of CT dynamic contrast-enhanced scan and pathological types,long-term prognosis of targeted therapy in non-small cell lung cancer
摘要
Abstract
Objective:To explore the relationship between quantitative parameters of CT dynamic contrast-enhanced scan and pathological types,long-term prognosis of targeted therapy in non-small cell lung cancer(NSCLC).Methods:A retrospective analysis was performed on the clinical data of 116 patients with NSCLC.All patients were treated with epidermal growth factor receptor(EGFR)for targeted therapy.Before and one month after treatment,CT dynamic contrast-enhanced scan was performed to obtain quantitative parameters,such as perfusion value,peak height(PH),time to peak(Tp).According to status of survival,all patients were divided into the death group(30 cases)and the survival group(86 cases).The relationships between perfusion value,PH,Tp and pathological types,long-term prognosis of targeted therapy were analyzed.Results:Before treatment,there were no significant differences in quantitative parameters of CT dynamic contrast-enhanced scan among patients with different pathological types(all P>0.05).After treatment,perfusion value and PH level decreased,while Tp level increased(all P<0.05).After treatment,perfusion value and PH level in the survival group were even lower than those in the death group,while Tp level was even higher than that in the death group(all P<0.05).ROC curve analysis showed that AUC and cut-off value of perfusion value for predicting long-term prognosis of NSCLC patients were 0.822 and 0.19 mL·min-1·mL-1,those of PH were 0.780 and 57.61 HU,and those of Tp were 0.741 and 89.92 s,respectively,and AUC of combined detection was 0.960,which was greater than that of single index(P<0.05).Conclusions:The quantitative parameters of CT dynamic contrast-enhanced scan are not related to pathological types,but are closely related to long-term prognosis of targeted therapy in NSCLC patients.关键词
癌,非小细胞肺/体层摄影术,X线计算机/动态增强扫描/定量参数/病理类型/靶向治疗/预后Key words
Carcinoma,non-small-cell lung/Tomography,X-ray computed/Dynamic contrast-enhanced scan/Quantitative parameter/Pathological type/Targeted therapy/Prognosis引用本文复制引用
温建安,舒进鹏,周旭嘉,陈涛,赵艳玲..非小细胞肺癌CT动态增强扫描定量参数与病理类型及靶向治疗远期预后的关系分析[J].中国中西医结合影像学杂志,2024,22(4):430-433,4.基金项目
十堰市市级引导性科技项目(22Y84). （22Y84）
