中国中医药信息杂志2024，Vol.31Issue(8)：152-157,6.DOI:10.19879/j.cnki.1005-5304.202402238
痹证颗粒联合西医基础疗法治疗神经根型颈椎病肝肾不足、痰湿交阻证临床研究
Clinical Study on Bizheng Granules Combined with Basic Therapy in the Treatment of Liver and Kidney Insufficiency and Phlegm-Dampness Cross-Blocking Syndrome of Nerve Root Type Cervical Spondylosis Radiculopathy
摘要
Abstract
Objective To evaluate clinical efficacy and safety of Bizheng Granules combined with basic therapy in the treatment of liver and kidney insufficiency and phlegm-dampness cross-blocking syndrome of nerve root type cervical spondylosis radiculopathy.Methods Totally 108 patients with nerve root type cervical spondylosis radiculopathy were selected and divided into Bizheng Granules group,Jingfukang Granules group,and Bizheng Granules placebo group according to random number table method,with 36 cases in each group.The three groups were treated with the basic treatment(oral methylcobalamin tablets of 0.5 mg,three times a day,and cervical spine intermittent traction once a day,each time for 15 min),and Bizheng Granules were given in the Bizheng Granules group,and Jingfukang Granules in the Jingfukang Granules group,and Bizheng Granules placebo in the Bizheng Granules placebo group,twice a day after meals.All three groups were treated continuously for 2 weeks and followed up at 4 and 12 weeks after treatment.Visual analog scale(VAS),cervical dysfunction index(NDI),and 36-items short form survey(SF-36)score were recorded in the 3 groups before and after treatment and 4 and 12 weeks after treatment,respectively.Adverse reactions during treatment and follow-up were recorded in the 3 groups.Results 3 cases lost in the Bizheng Granules group,3 cases in the Jingfukang Granules group,and 1 case in the Bizheng Granules placebo group.Compared with the pre-treatment period,the differences in VAS score,NDI score,and SF-36 score among the three groups of patients at all time points of treatment and follow-up were statistically significant(P<0.05).At 12 weeks after treatment,the VAS score and NDI score of the Bizheng Granules group and the Jingfukang Granules group were lower than those of the Bizheng Granules placebo group,but the differences in VAS score and NDI score between Bizheng Granules group and Jingfukang Granules group were not statistically significant(P>0.05).12 weeks after treatment,the SF-36 score of Bizheng Granules group were higher than those of Bizheng Granules placebo group,but the difference in SF-36 score between Bizheng Granules group and Jingfukang Granules group was not statistically significant(P>0.05).The total effective rate of Bizheng Granules group was better than that of the Jingfukang Granules group and Bizheng Granules placebo group(P<0.05).The incidence of adverse reactions in the three groups was not statistically significant(P>0.05).There were no serious adverse events in the three groups.Conclusion Bizheng Granules combined with basic therapy has a definite therapeutic effect in improving pain,restoring cervical dysfunction,and improving quality of life in the treatment of liver and kidney insufficiency and phlegm-dampness cross-blocking syndrome of nerve root type cervical spondylosis radiculopathy,with good safety.关键词
神经根型颈椎病/痹证颗粒/随机对照试验Key words
cervical spondylosis radiculopathy/Bizheng Granules/RCTs分类
医药卫生引用本文复制引用
薛瑞瑞,张书铭,都基勋,房圆,许金海,莫文,施杞..痹证颗粒联合西医基础疗法治疗神经根型颈椎病肝肾不足、痰湿交阻证临床研究[J].中国中医药信息杂志,2024,31(8):152-157,6.基金项目
上海中医药大学第三轮学术荣誉体系特聘教授计划(2024年) （2024年）
上海市浦东新区卫生健康委员会联合攻关科研项目(PW2021D-11) （PW2021D-11）
上海市浦东新区中医药传承创新发展示范试点建设项目(YC-2023-0901) （YC-2023-0901）
国家中医药管理局高水平中医药重点学科建设项目(ZYYZDXK-2023059) （ZYYZDXK-2023059）
上海神志病研究合作课题(SZB202202) （SZB202202）
