中国中药杂志2024，Vol.49Issue(14)：3693-3705,13.DOI:10.19540/j.cnki.cjcmm.20240412.601
香豆素类化合物的生物合成关键酶及活性研究进展
Research progress in biosynthesis-related enzymes of coumarin compounds and their bioactivities
摘要
Abstract
Coumarins are natural products with benzopyran ring as the parent nucleus.Numerous coumarin derivatives exhibit a va-riety of pharmacological activities,including antibacterial,anti-inflammatory,antitumor,anti-coagulant,anti-osteoporotic,and insecti-cidal activities.Therefore,they play an important role in both medicine and agriculture.The development and utilization of coumarin derivatives have attracted increasing attention.The advancement of gene sequencing technology and the rapid progress in synthetic bio-logy have led to significant advancement in the biosynthesis of coumarin derivatives,and has received increasing attention from global researchers.This paper presents a comprehensive overview of the key biosynthesis-related enzymes of coumarin derivatives,such as cy-tochrome P450 enzyme(CYP450),prenyltransferase(PT),UDP-glucosyltransferase(UGT).Additionally,the pharmacological ac-tivities of these enzymes,including anti-tumor,anti-inflammatory,antioxidant,and antibacterial activities,are systematically summa-rized.This review aims to provide a valuable reference for the biosynthesis of coumarin derivatives and further exploration of their me-dicinal potential.关键词
香豆素/细胞色素P450酶/异戊烯基转移酶/葡萄糖基转移酶/生物活性Key words
coumarin/cytochrome P450 enzyme/prenyltransferase/glucosyltransferase/bioactivity引用本文复制引用
吕华伟,梁慧敏,朱梦迪,王鸿,李行诺..香豆素类化合物的生物合成关键酶及活性研究进展[J].中国中药杂志,2024,49(14):3693-3705,13.基金项目
国家重点研发计划项目(2022YFC2804204) （2022YFC2804204）
浙江省基础公益研究计划项目(ZCLTGC24H2801) （ZCLTGC24H2801）
