中成药2024，Vol.46Issue(7)：2220-2224,5.DOI:10.3969/j.issn.1001-1528.2024.07.015
苓泽降脂汤联合多烯磷脂酰胆碱胶囊对非酒精性脂肪性肝病患者的临床疗效
Clinical effects of Lingze Jiangzhi Decoction combined with Polyene Phosphatidylcholine Capsules on patients with non-alcoholic fatty liver disease
摘要
Abstract
AIM To explore the clinical effects of Lingze Jiangzhi Decoction combined with Polyene Phosphatidylcholine Capsules on patients with non-alcoholic fatty liver disease.METHODS Eighty patients were randomly assigned into control group(40 cases)for 3-month administration of Polyene Phosphatidylcholine Capsules,and observation group(40 cases)for 3-month administration of both Lingze Jiangzhi Decoction and Polyene Phosphatidylcholine Capsules.The changes in clinical effects,blood lipid indices(TC,HDL-C,LDL-C,TG),blood glucose indices(HbA1c,FPG),LPS,oxidative stress indices(T-AOC,SOD,NO),insulin sensitivity indices(GLUT4,IRS1,IRS2),liver function indices(ALT,AST),liver injury indices(γ-2GT,TGF-β,LEP,nuclear factor κB)and TCM symptom scores were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased TC,LDL-C,TG,blood glucose indices,LPS,NO,liver function indices,liver injury indices,TCM symptom scores(P＜0.05),and decreased HDL-C,T-AOC,SOD,insulin sensitivity indices(P＜0.05),especially for the observation group(P＜0.05).CONCLUSION For the patients with non-alcoholic fatty liver disease,Lingze Jiangzhi Decoction combined with Polyene Phosphatidylcholine Capsules can improve glucose and lipid metabolism,insulin sensitivity,liver functions,inhibit inflammation,reduce oxidative stress injury,liver injury,and enhance clinical efficacy.关键词
苓泽降脂汤/联合多烯磷脂酰胆碱胶囊/非酒精性脂肪性肝病Key words
Lingze Jiangzhi Decoction/Polyene Phosphatidylcholine Capsules/non-alcoholic fatty liver disease分类
医药卫生引用本文复制引用
邢东,刘建伟..苓泽降脂汤联合多烯磷脂酰胆碱胶囊对非酒精性脂肪性肝病患者的临床疗效[J].中成药,2024,46(7):2220-2224,5.基金项目
甘肃省科技公关计划项目(20YF3FA015) （20YF3FA015）
