中成药2024，Vol.46Issue(7)：2252-2258,7.DOI:10.3969/j.issn.1001-1528.2024.07.022
白毛藤化学成分及其抗肿瘤活性研究
Chemical constituents from Solanum lyratum and their anti-tumor activities
摘要
Abstract
AIM To study the chemical constituents from Solanum lyratum Thunb.and their anti-tumor activities.METHODS The extract from S.lyratum was isolated and purified by silica gel column chromatography and Sephadex LH-20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The anti-tumor activities were determined by MTT mothod.RESULTS Twenty-one compounds were isolated and identified as royleanone(1),dinbutyl phthalate(2),dipentyl phthalate(3),sativan(4),2′,4′-dihydroxy-chalcone(5),isopetasin(6),balanophonin(7),10-eicosenoic acid(8),4,6,7-trimethoxy-5-methyl-coumarin(9),hydroxydihydrobovolide(10),axillarin(11),xanthocyanin(12),magnoflorine(13),verlinic acid(14),apigenin(15),luteolin(16),7-ketositosterol(17),pinoresinol(18),bavachinine(19),bisbenzopyran(20),isotachioside(21).The IC50 values of compounds 6-7,11 and 18-19 ranged from(28.37±3.71)to(73.26±8.61)μmol/L.CONCLUSION All the compounds are first isolated from this plant.Compounds 6-7,11 and 18-19 have certain anti-tumor activities.关键词
白毛藤/化学成分/分离鉴定/抗肿瘤活性Key words
Solanum lyratum Thunb./chemical constituents/isolation and identification/anti-tumor activities分类
医药卫生引用本文复制引用
张林果,王福安,乔曼华,郝丽亚,刘丽..白毛藤化学成分及其抗肿瘤活性研究[J].中成药,2024,46(7):2252-2258,7.基金项目
河南省高等学校重点科研项目(21B310005) （21B310005）
河南省医学教育研究项目(Wjlx2020290) （Wjlx2020290）
平顶山学院教学改革研究项目(2020-JY12) （2020-JY12）
