中成药2024，Vol.46Issue(7)：2265-2271,7.DOI:10.3969/j.issn.1001-1528.2024.07.024
潞党参化学成分及其抗炎活性研究
Chemical constituents from Codonopsis pilosula in Shanxi and their anti-inflammatory activities
摘要
Abstract
AIM To study the chemical constituents from Codonopsis pilosula(Franch.)Nannf in Shanxi and their anti-inflammatory activities.METHODS The 70％ ethanol extract from C.pilosula in Shanxi was isolated and purified by silica gel,ODS and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Their in vitro anti-inflammatory activities were evaluated by RAW264.7 model.RESULTS Sixteen compounds were isolated and identified as ethylsyringin(1),7-O-ethyltangshenoside Ⅱ(2),triandrin(3),trans-isoconiferin(4),methylsyringin(5),9-acetoxy syringin(6),cordifolioidyne B(7),codonopiloenynenoside A(8),codonopilodiynoside F(9),pratialin B(10),lobetyolinin(11),lariciresinol-4-O-β-D-glucoside(12),dihydrodehydrodiconiferyl alcohol 4′-O-β-D-glucoside(13),atractylenolid Ⅲ(14),baimantuoluoamide B(15),benzyl primeveroside(16).Compounds 1-2,5,7-11 and 13-15 had certain anti-inflammatory activities,among which compounds 11,14-15 had higher activities,whose IC50 values were(18.23±4.18),(17.73±3.12),(14.89±2.47)μmol/L,respectively.CONCLUSION Compounds 3,6,13,16 are first isolated from Campanulaceae,2,5,15 are first found from this plant.Compounds 11,14 and 15 have good anti-inflammatory activities.关键词
潞党参/化学成分/分离鉴定/抗炎活性Key words
Codonopsis pilosula(Franch.)Nannf in Shanxi/chemical constituents/isolation and identification/anti-inflammatory activities分类
医药卫生引用本文复制引用
程艳刚,李佩,杨思琦,孔祥鹏,李慧峰,王艳,谭金燕,王颖莉..潞党参化学成分及其抗炎活性研究[J].中成药,2024,46(7):2265-2271,7.基金项目
山西省教育厅科技创新计划(2021L359) （2021L359）
山西省科技创新人才团队专项计划(202204051002028) （202204051002028）
山西省卫生健康委员会重点实验室建设计划(2021SYS23) （2021SYS23）
山西中医药大学博士科研启动基金(2022BK14) （2022BK14）
山西中医药大学科技创新团队(2022TD1015) （2022TD1015）
山西中医药大学学科建设(2024XKJS-26) （2024XKJS-26）
