中成药2024，Vol.46Issue(7)：2278-2283,6.DOI:10.3969/j.issn.1001-1528.2024.07.026
望春花花蕾化学成分及其乙酰胆碱酯酶体外抑制活性研究
Chemical constituents from the flower buds of Magnolia biondii and their in vitro acetylcholinesterase inhibitory activities
摘要
Abstract
AIM To study the chemical constituents from flower buds of Magnolia biondii Pamp.and their in vitro acetylcholinesterase inhibitory activities.METHODS The 50% acetone extract from the flower buds of M.biondii was isolated and purified by Diaion HP-20,Toyopearl HW-40C,ODS and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The in vitro acetylcholinesterase inhibitory activities of these compounds were determined according to previous method established by research group.RESULTS Seventeen compounds were isolated and identified as crassifolioside(1),magnoloside B(2),rutin(3),isoquercitrin(4),quercetin(5),northalifoline(6),cordysinin B(7),thymidine(8),indazole(9),dihydrodehydrodiconiferyl alcohol(10),aesculetin(11),C-veratroylglycol(12),3,4-dihydroxyphenylethanol(13),3-methoxy-4-hydroxyphenylethanol(14),3,4-dihydroxybenzoic acid(15),2,4,6-trimethoxyphenol(16),syringic acid(17).CONCLUSION Compounds 1-17 are isolated from this plant for the first time,none of which show acetylcholinesterase inhibitory activities at the concentration of 20 μmol/L.关键词
望春花/花蕾/化学成分/分离鉴定/乙酰胆碱酯酶Key words
Magnolia biondii Pamp./flower buds/chemical constituents/isolation and identification/acetylcholinesterase分类
医药卫生引用本文复制引用
曹彦刚,王建超,王梦娜,何玉环,李红伟,郝志友,郑晓珂,冯卫生..望春花花蕾化学成分及其乙酰胆碱酯酶体外抑制活性研究[J].中成药,2024,46(7):2278-2283,6.基金项目
国家自然科学基金项目(82003946) （82003946）
2016年中央引导地方科技发展专项项目(豫财科[2016]149号) （豫财科[2016]149号）
