摘要
Abstract
Objective To analyze the distribution and drug resistance of bloodstream infection pathogens in the laboratory of the First People's Hospital of Aksu region from January 1,2022 to June 30,2023,and to provide scientific reference for clinical rational drug use.Methods The data of pathogens isolated from 2454 patients with bloodstream infection were analyzed retrospectively,focusing on the drug resistance of Escherichia coli,Staph-ylococcus aureus,Klebsiella pneumoniae,Enterobacter cloacae,Streptococcus pneumoniae,Enterococcus faecium(Group D),and other major pathogens.Results Among 2454 patients with bloodstream infection,Escherichia coli accounted for 26.00％,Staphylococcus aureus accounted for 11.70％,Klebsiella pneumoniae accounted for 10.47％,Staphylococcus hominis accounted for 9.01％,Staphylococcus epidermidis accounted for 5.58％,Brucel-la melitensis accounted for 4.44％,Enterobacter cloacae accounted for 3.18％,Streptococcus pneumoniae account-ed for 2.89％,and fungi and other unclassified pathogens accounted for 15.45％.Drug resistance of gram-positive bacilli in bloodstream infection:the drug resistance rate of Escherichia coli to ceftriaxone was 43.40％,and the drug re-sistance rate to ampicillin was 73.61％;The resistance rates of Klebsiella pneumoniae to ceftazidime and imipenem were 57.14％and 25.88％,respectively.The resistance rates of Enterobacter cloacae to ceftazidime and imi-penem were 27.27％and 15.62％,respectively.Drug resistance of gram-negative bacilli in bloodstream infec-tion:the drug resistance rate of Staphylococcus aureus to penicillin G was 89.62％,and the drug resistance rates to vancomycin and linezolid were 0％;The resistance rate of Streptococcus pneumoniae to tetracycline was 72.22％,and the resistance rate to vancomycin and linezolid was also 0％.The resistance rate of Enterococcus faecium to penicillin G was as high as 97.22％,to ciprofloxacin and levofloxacin were 79.31％and 79.31％respectively,and to vancomycin was 2.77％.Conclusion The drug resistance of pathogens in bloodstream infection is diversified,and the clinical medication should be individualized according to the types of pathogens and their drug resistance characteristics,so as to improve the therapeutic effect and reduce the occurrence of drug resistance.At the same time,strengthening the monitoring of drug resistance of pathogenic bacteria and providing scientific basis for clinical med-ication are the key measures to reduce the mortality of patients with bloodstream infection.关键词
感染/抗菌药/发病率Key words
infection/anti-bacterial agents/incidence分类
医药卫生
