沉默信息调节因子1调控小窝蛋白-1对大鼠急性肺损伤的影响OACSTPCD
Effect of silence infor-mation regulator 1 on lipopolysaccharide-induced acute lung injury rats via regulating caveolin-1
目的 探讨沉默信息调节因子1(SIRT1)调控小窝蛋白-1(Cav-1)对脂多糖(LPS)所致大鼠急性肺损伤(ALI)的影响.方法 采用随机数字表法将40只SD大鼠分为对照组(NS组)、LPS组(L组)、LPS+SIRT1激动剂SRT1720组(S组)和LPS+SIRT1抑制剂EX527组(E组),每组各10只.S组和E组大鼠分别尾静脉注射SRT1720 10 mg/kg、EX527 1 μg/kg,30 min后L组、S组和E组滴鼻LPS 5 …查看全部>>
Objective To investigate the effect of silence infor-mation regulator 1(SIRT1)on lipopolysaccharide(LPS)-induced acute lung injury(ALI)rats via regulating caveolin-1(Cav-1).Methods Forty male Sprague-Dawley rats were divided into 4 groups:normal saline group(group NS),LPS group(group L),LPS+SIRT1 activator SRT1720-pretreated group(group S),and LPS+SIRT1 inhibitor EX527-pretreated group(group E),10 in each group.The animals in groups S and E received intraven…查看全部>>
费国方;刘静;童飞;黄新华
313000 湖州市妇幼保健院麻醉科313000 湖州市妇幼保健院麻醉科湖州市中心医院麻醉科313000 湖州市妇幼保健院麻醉科
沉默信息调节因子1小窝蛋白-1Toll样受体4脂多糖急性肺损伤
Silence infor-mation regulator 1Caveolin-1Toll-like receptor 4LipopolysaccharideAcute lung injury
《浙江医学》 2024 (13)
1357-1361,1386,后插1,7
浙江省医药卫生科技计划项目(2023KY315)湖州市应急科技计划项目(2020GZT02)
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