停乳链球菌似马亚种致医院感染的临床特点与药物敏感性研究OACSTPCD

Objective To investigate the clinical characteristics of hospital infection caused by Streptococcus dysgalactiae subspecies equisimilis(SDSE)and drug sensitivity,in order to improve the understanding of clinicians to SDSE and provide evidence for clinical anti-infection treatment.Methods Clinical data of 49 patients from whom SDSE was isolated in clinical Department of the Second Hospital of Jinhua from January 2020 to December 2022 were retrospectively analyzed,and the sensitivity of SDSE to 19 antibacterial agents was determined by Kirby-Bauer(K-B)disk diffusion method.Results SDSE-infected patients were mainly aged ≥60 years,with a history of invasive operations(or previous operations),a history of chemoradiotherapy,application of broad-spectrum antibiotics and/or hormones for ≥4 weeks,and serious underlying diseases.Their main clinical manifestations were fever,chills,cough,headache,etc.SDSE strains were mainly derived from sputum(46.94％),blood(22.45％)and urine(14.29％),and were mainly found in Intensive Care Unit(28.57％),Medical Oncology Department(24.49％),Dermatology Department(14.29％)and Infectious Disease Department(10.20％).According to the drug sensitivity test,no SDSE resistance to vancomycin,linezolid,quinupristin/dalfopristin,furantoin,cefzolin,ceftriaxone,cefepime,penicillin G,amoxicillin and tigecycline were observed,but it was 100.00％resistant to erythromycin and clindamycin.Its drug resistance rates to gentamicin,tetracycline,rifampicin,chloramphenicol,cotrimoxazole,levofloxacin and ciprofloxacin were all lower than 45.00％,and the drug resistance rates of SDSE against the above seven tested drugs showed a significant increasing trend from 2020 to 2022(all P＜0.05).SDSE-infected patients treated with ceftriaxone,penicillins,levofloxacin and other antibacterial drugs were all cured or improved.Conclusion SDSE infection mainly targets immunocompromised patients with non-specific clinical manifestations and high sensitivity to most antibiotics.β-lactam drugs can be used as the first choice for the treatment of SDSE infection.