肿瘤防治研究2024，Vol.51Issue(7)：567-572,6.DOI:10.3971/j.issn.1000-8578.2024.23.1053
孟德尔随机化探究Omega-3脂肪酸与乳腺癌发病风险的因果关系
Causal Association Between Omega-3 Fatty Acids and Risk of Breast Cancer:A Mendelian Randomization Study
王嘉琪 1唐伟 2黄晓 1符德元3
作者信息
- 1. 225009 扬州,扬州大学医学院
- 2. 116044 大连,大连医科大学研究生院
- 3. 225002 扬州,苏北人民医院甲乳外科
- 折叠
摘要
Abstract
Objective To explore the causal relationship between Omega-3 fatty acids and the risk of breast cancer via Mendelian randomization analysis.Methods Analysis was conducted on data from genome-wide association studies(GWASs)on Omega-3 fatty acids and breast cancer.The selected instrumental variables(IVs)comprised genetic loci associated with Omega-3 fatty acids.Various Mendelian randomization analysis methods,including inverse-variance weighted(IVW)method,MR-Egger regression analysis,weighted median,simple models,and weighted models,were used to evaluate the causal relationship between Omega-3 fatty acids and the risk of breast cancer.Results A total of 47 single-nucleotide polymorphisms strongly associated with Omega-3 fatty acids were selected as IVs.The analysis methods,including IVW method,revealed no causal relationship between Omega-3 fatty acids and the risk of breast cancer(P>0.05).Analysis methods,such as MR-Egger regression analysis,did not detect significant gene-level pleiotropy(P=0.319),which indicates the high sensitivity and robustness of analysis results.Conclusion The findings of this study suggest the absence of a causal relationship between Omega-3 fatty acids and the risk of breast cancer.关键词
Omega-3脂肪酸/乳腺癌/孟德尔随机化/全基因组关联研究Key words
Omega-3 fatty acids/Breast cancer/Mendelian randomization/Genome-wide association studies分类
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王嘉琪,唐伟,黄晓,符德元..孟德尔随机化探究Omega-3脂肪酸与乳腺癌发病风险的因果关系[J].肿瘤防治研究,2024,51(7):567-572,6.
