基于UPLC-QqQ-MS/MS测定人参属中药对甲亢大鼠类固醇激素含量的影响OA北大核心CSTPCDEI
Quantitative Analysis of Steroid Hormones to Explore the Effects of Ginseng Medicines Base on UPLC-QqQ-MS/MS
本研究利用超高效液相色谱-三重四极杆串联质谱(UPLC-QqQ-MS/MS)联用技术定量测定甲亢大鼠血清中肾上腺素和多种类固醇激素,探讨血清中类固醇激素含量与甲状腺功能亢进的相关性,以及不同药性人参属中药红参和人参叶对甲亢高代谢的改善作用.采用主成分分析(PCA)、Spearman检验进行肾上腺素和类固醇激素与甲状腺功能的相关性分析.结果表明,UPLC-QqQ-MS/MS能够快速检测待测物的含量和变化,灵敏度高、重现性好、准确率高且分析速度快.与…查看全部>>
The medicinal nature of traditional Chinese medicine(TCM)mainly plays a role in regulating the energy and material metabolism of the body.The energy metabolism of the body is also regulated by the nervous and endocrine systems,and the hormones are an important component of the endocrine system to realize the coordinated action.Therefore,the medicinal nature of TCM is inextricably linked with the metabolism of hormones.Hyperthyroidism,qi-yin deficiency syndro…查看全部>>
金墨竹;刘琳琳;窦德强
辽宁中医药大学药学院,辽宁大连 116600辽宁中医药大学药学院,辽宁大连 116600辽宁中医药大学药学院,辽宁大连 116600
化学
甲亢肾上腺素类固醇激素超高效液相色谱-三重四极杆串联质谱(UPLC-QqQ-MS/MS)红参人参叶定量测定
hyperthyroidismadrenalinesteroid hormoneultra-performance liquid chromatography tandem triple quaternary mass spectrometry(UPLC-QqQ-MS/MS)red ginsengginseng leavesquantitative analysis
《质谱学报》 2024 (4)
540-551,12
国家自然科学基金(82073985)辽宁省重点研发计划项目(2023JH2/10300058)
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