中国现代医生2024，Vol.62Issue(19)：13-16,42,5.DOI:10.3969/j.issn.1673-9701.2024.19.003
联合运动训练对慢性阻塞性肺疾病合并肌少症老年患者运动能力和炎症因子的影响
Effects of combined exercise training on exercise ability and inflammatory factors in elderly patients with chronic obstructive pulmonary disease complicated with sarcopenia
摘要
Abstract
Objective To investigate the effects of combined exercise training on exercise ability and inflammatory factors in elderly patients with chronic obstructive pulmonary disease(COPD)complicated with sarcopenia.Methods Sixty elderly patients with COPD complicated with sarcopenia who were treated in Hangzhou Third People's Hospital from July 2022 to May 2023 were selected as study objects,and were divided into control group and treatment group according to random number table method,with 30 cases in each group.The control group received routine treatment of COPD,while the treatment group received combined exercise training on the basis of routine treatment for 12 weeks.The appendicular skeletal muscle mass index(ASMI),grip strength,walking speed,6 min walking distance(6MWD),COPD assessment test(CAT),forced expiratory volume in one second(FEV1)/forced vital capacity(FVC)、serum interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were compared.The correlation between serum IL-6、TNF-α and ASMI,grip strength、walking speed were analyzed.Results After treatment,6MWD in both groups was significantly longer than before treatment,and CAT score was significantly lower than before treatment(P＜0.05).The ASMI,grip strength and walking speed of patients in treatment group were significantly higher than before treatment,and the serum IL-6 and TNF-α were significantly lower than before treatment(P＜0.05).The ASMI,grip strength and walking speed of treatment group were significantly higher than those of control group,6MWD was significantly longer than that of control group,CAT score,serum IL-6 and TNF-α were significantly lower than those of control group(P＜0.05).There was no significant difference in FEV1/FVC between two groups before and after treatment(P＞0.05).Pearson correlation analysis showed that serum IL-6、TNF-α were negatively correlated with ASMI、grip strength and walking speed.Conclusion Combined exercise training can improve muscle mass and strength,improve exercise ability and clinical symptoms,and inhibit inflammatory response in elderly patients with COPD complicated with sarcopenia.关键词
慢性阻塞性肺疾病/肌少症/有氧运动/抗阻运动/炎症因子Key words
Chronic obstructive pulmonary disease/Sarcopenia/Aerobic exercise/Resistant exercise/Inflammatory factor分类
医药卫生引用本文复制引用
任谦,王琴,林萍,孔程程,陈娜,张彬,金益萍..联合运动训练对慢性阻塞性肺疾病合并肌少症老年患者运动能力和炎症因子的影响[J].中国现代医生,2024,62(19):13-16,42,5.基金项目
浙江省医药卫生科技计划项目(2019KY502) （2019KY502）
杭州市科技计划引导项目(20211231Y033) （20211231Y033）
