中国现代医生2024，Vol.62Issue(19)：37-42,6.DOI:10.3969/j.issn.1673-9701.2024.19.008
阴部神经电针联合托特罗定治疗女性膀胱过度活动症
The effect of perineal nerve electroacupuncture combined with tolterodine in the treatment of female overactive bladder
摘要
Abstract
Objective To investigate the effect of perineal nerve electroacupuncture combined with tolterodine in the treatment of female overactive bladder(OAB).Methods A total of 150 female OAB patients treated in Huzhou Hospital of Traditional Chinese Medicine,Zhejiang Chinese Medical University from April 2020 to May 2021 were selected and divided into control group and study group according to random number table method,with 75 cases in each group.The control group was treated with tolterodine,and the study group was treated with pudendal nerve electroacupuncture combined with tolterodine.Clinical symptoms,urinary symptoms,and urodynamic indicators[maximum cystometric capacity(MCC),maximum urethral closure pressure(Pura clos max),maximum detrusor pressure(Pdet max),and maximum urine flow rate(Qmax)],bladder function indicators(initial bladder sensation volume,bladder volume during strong micturition desire),nerve growth factor(NGF)mediated transient receptor potential(TRP)pathway indicators[NGF,NGF/urine creatinine(UCr),TRPV1,TRPV4]and clinical efficacy of two groups were compared.Results After treatment,the number of night urination and urgent urination in study group were significantly less than those in control group,and the average volume of urination was significantly more than that in control group(P＜0.05).The overactive bladder symptom scores and visual analogue scale scores of study group were significantly lower than those of control group(P＜0.05).The MCC and Pura·clos·max in study group were significantly higher than those in control group,while Pdet max and Qmax were significantly lower than those in control group(P＜0.05).The initial bladder sensation volume and bladder volume during strong micturition desire in study group were higher than those in control group(P＜0.05).NGF,NGF/UCr,positive expression rates of TRPV1 and TRPV4 in study group were lower than those in control group(P＜0.05).The total effective rate was significantly higher in study group than in control group,(x2=5.374,P=0.020).There was no significant difference in the incidence of total adverse reactions between two groups(x2=0.362,P=0.547).Conclusion Perineal nerve electroacupuncture combined with tolterodine can significantly improve bladder function and inhibit clinical symptoms in female OAB patients,possibly by inhibiting bladder sensitivity caused by NGF-mediated increase of TRP channel proteins TRPV1 and TRPV4.关键词
膀胱过度活动症/阴部神经电针疗法/托特罗定/神经生长因子/瞬时受体电位Key words
Overactive bladder/Perineal nerve electroacupuncture therapy/Tolterodine/Nerve growth factor/Transient receptor potential分类
医药卫生引用本文复制引用
吕笑,姚丽娟,王勇伟,赵良伟..阴部神经电针联合托特罗定治疗女性膀胱过度活动症[J].中国现代医生,2024,62(19):37-42,6.基金项目
浙江省湖州市科技局资助项目(2019GYB35) （2019GYB35）
