摘要
Abstract
Objective:To study the effect of Recombinant Human Erythropoietin combined with vitamin D on peritoneal dialysis patients with renal anemia.Method:A total of 120 patients with peritoneal dialysis renal anemia treated in Jinjiang Hospital from January 2022 to June 2023 were selected and divided into observation group[active vitamin D(Calcitriol)+Recombinant Human Erythropoietin injection treatment]and control group(Recombinant Human Erythropoietin injection treatment)by random number table method,with 60 cases in each group.Blood cell conditions[hemoglobin(Hb),red blood cell count(RBC),hematocrit(HCT)],iron metabolism indexes[serum hepcidin,serum iron(SI),serum ferritin(SF)],thyroid hormone levels[serum free triiodothyronine(FT3),serum free thyroxine(FT4),thyrotropin(TSH),total parathyroid hormone(PTH)]before and after treatment and the occurrence of adverse reactions between the two groups were compared.Result:After treatment,Hb,RBC and HCT levels in two groups were higher than those before treatment,and Hb and RBC levels in observation group were higher than those in control group,the differences were statistically significant(P<0.05).After treatment,serum hepcidin and SF were lower than those before treatment,SI was higher than that before treatment,and serum hepcidin and SF in observation group were lower than those in control group,SI was higher than that in control group,the differences were statistically significant(P<0.05).After treatment,TSH,FT3 and FT4 of the two groups were higher than those before treatment,and PTH was lower than that before treatment,and TSH and FT4 of the observation group were higher than those of the control group,and PTH was lower than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(χ2=1.345,P=0.246).Conclusion:Recombinant Human Erythropoietin combined with vitamin D can significantly improve blood cell indexes,regulate iron metabolism and thyroid hormone levels in patients with peritoneal dialysis renal anemia,and no obvious adverse reactions were observed.关键词
维生素D/肾性贫血/腹膜透析/铁调素/甲状腺激素Key words
Vitamin D/Renal anemia/Peritoneal dialysis/Hepcidin/Thyroid hormone
