中外医学研究2024，Vol.22Issue(16)：179-184,6.DOI:10.14033/j.cnki.cfmr.2024.16.045
T淋巴细胞免疫在COPD肺气肿发病机制中的作用
Role of T Lymphocyte Immunity in the Pathogenesis of COPD Emphysema
摘要
Abstract
Emphysema is a typical pathological change of chronic obstructive pulmonary disease(COPD),and its occurrence and development cannot be separated from the participation of immune inflammation.T lymphocytes are closely related to the abnormal immunoinflammatory response of COPD emphysema.Different subtypes of CD8+T and CD4+T cells can secrete specific cytokines[such as granase,perforin,interferon-γ(INF-γ),tumor necrosis factor-α(TNF-α),interleukin-17(IL-17),etc.];it plays a crucial role in promoting alveolar cell apoptosis,regulating immune response and maintaining lung inflammation.This article reviews the recent progress of T lymphocyte mediated adaptive immunity in the pathogenesis of COPD emphysema,aiming to provide new ideas for the prevention and treatment of COPD emphysema.关键词
慢性阻塞性肺疾病/肺气肿/T淋巴细胞/免疫炎症Key words
Chronic obstructive pulmonary disease/Emphysema/T lymphocytes/Immune inflammation引用本文复制引用
王亮亮,宋春雪,丁琦,魏霞..T淋巴细胞免疫在COPD肺气肿发病机制中的作用[J].中外医学研究,2024,22(16):179-184,6.基金项目
西安市卫生健康委员会青年培育项目(2023qn10) （2023qn10）
西安市科技计划项目(21YXYJ0070) （21YXYJ0070）
