摘要
Abstract
Objective:To investigate the clinical effect of continuous positive airway pressure(CPAP)in the treatment of children with left-to-right shunt congenital heart disease(CHD)complicated with severe pneumonia.Method:A retrospective study was conducted on 107 children with left-to-right shunt CHD complicated with severe pneumonia admitted to the PICU of Guizhou Provincial People's Hospital from November 2021 to April 2023.They were divided into experimental group(n=26)and control group(n=81)according to different treatment methods.Both groups received conventional treatment,with the experimental group receiving CPAP therapy and the control group receiving nasal catheter oxygen inhalation therapy.Blood gas analysis indicators,relevant clinical indicators 30 min before treatment(pre-treatment)and 1 d after treatment,time indicators were compared between the two groups.Result:After 1 d of treatment,blood lactic acid(Lac)and arterial blood partial pressure of carbon dioxide(PaCO2)in both groups were decreased,and oxygenation index was increased,Lac and PaCO2 in experimental group were lower than those in control group,and oxygenation index was higher than that in control group,the differences were statistically significant(P<0.05).After 1 d of treatment,the heart rate(HR)and respiratory rate(RR)of both groups were decreased,and the HR and RR of the experimental group were lower than those of the control group;after 7 d of treatment,natriuretic peptide(BNP)of both groups was decreased,BNP of the experimental group was lower than that of the control group,left ventricular ejection fraction(LVEF)of both groups were increased,and LVEF of the experimental group was was higher than that of the control group,the differences were statistically significant(P<0.05).The PICU check-in time,the improvement time of dyspnea and mental of experimental group were shorter than those of control group,the differences were statistically significant(P<0.05).Conclusion:CPAP has significant clinical effects in children with left-to-right shunt CHD complicated with severe pneumonia,and can effectively improve left ventricular function,shorten hospital stay,and reduce the duration of clinical symptoms.关键词
持续气道正压/左向右分流/先天性心脏病/重症肺炎Key words
Continuous positive airway pressure/Left-to-right shunt/Congenital heart disease/Severe pneumonia
