阿托伐他汀钙片治疗老年白内障术后患者的效果OA
Effect of Atorvastatin Calcium Tablets in the Treatment of Elderly Patients after Cataract Surgery
目的:研究阿托伐他汀钙片治疗老年白内障术后患者的效果.方法:选择 2020 年 1 月—2022 年 1 月南漳县中医医院眼科收治的 88 例拟行手术治疗的老年白内障患者作为研究对象,按照随机数表法分为两组,各 44 例.所有患者均行超声乳化手术,观察组在术后给予阿托伐他汀钙片口服,对照组不另外服药.比较两组治疗效果、术后不同时段黄斑中心凹视网膜厚度(CRT)、最佳矫正视力(BCVA)、血脂水平[总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)].结果:观察组治疗总有效率为 95.45%,显著高于对照组的 81.82%,差异有统计学意义(P<0.05).术后 3 周、12 周、24 周,两组CRT均高于术后 1 d,但观察组低于对照组;术后 12周、24周,两组CRT低于术后3周;术后24周,两组CRT均低于术后12周,差异有统计学意义(P<0.05).术后1周、3 周、6 周,两组BCVA均高于术前;术后 3 周、6 周,两组BCVA均高于术后 1 周;术后 6 周,两组BCVA均高于术后 3 周;术后 3 周、6 周,观察组BCVA均高于对照组,差异有统计学意义(P<0.05).术后 12 周,两组TC、LDL-C水平均低于术前,HDL-C水平高于术前,且观察组TC、LDL-C水平均低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05).结论:老年白内障患者术后应用阿托伐他汀钙片可有效控制患者血脂水平,从而改善视力,降低黄斑水肿发生风险,提升治疗效果.
Objective:To study the effect of Atorvastatin Calcium Tablets in the treatment of elderly patients after cataract surgery.Method:A total of 88 elderly cataract patients who were underwent surgical treatment in the Ophthalmology Department of Nanzhang County Hospital of Traditional Chinese Medicine from January 2020 to January 2022 were selected as the study objects and divided into two groups according to random number table method,with 44 cases in each group.All patients underwent phacoemulsification.The observation group was given Atorvastatin Calcium Tablets after surgery,while the control group was given no additional medication.The treatment effect,the fovea center retinal thickness(CRT),the best corrected visual acuity(BCVA),and the level of blood lipid[total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)]were compared between the two groups.Result:The total effective rate of the observation group was 95.45%,which was significantly higher than 81.82%of the control group,and the difference was statistically significant(P<0.05).At 3 weeks,12 weeks and 24 weeks after surgery,CRT in both groups were higher than those at 1 d after surgery,but the observation group were lower than those in the control group;at 12 weeks and 24 weeks after surgery,CRT in the groups were lower than that at 3 weeks after surgery;and at 24 weeks after surgery,CRT in the two groups were lower than that at 12 weeks after surgery,the differences were statistically significant(P<0.05).At 1 week,3 weeks and 6 weeks after surgery,BCVA in both groups were higher than those before surgery;at 3 weeks and 6 weeks after surgery,BCVA in both groups were higher than that at 1 week after surgery;at 6 weeks after surgery,BCVA in both groups were higher than those at 3 weeks after surgery;at 3 weeks and 6 weeks after operation,BCVA in observation group were higher than those in the control group,the differences were statistically significant(P<0.05).At 12 weeks after surgery,the levels of TC and LDL-C in both groups were lower than those before surgery,and the levels of HDL-C were higher than that before surgery,and the levels of TC and LDL-C in the observation group were lower than those in the control group,and the levels of HDL-C was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion:The application of Atorvastatin Calcium Tablets after surgery in elderly cataract patients can effectively control the blood lipid level of patients,thereby improving vision,reducing the risk of macular edema and improving the therapeutic effect.
吴启红;郭良晨;丁圣星;王丹
南漳县中医医院 湖北 南漳 441500
阿托伐他汀老年人白内障黄斑水肿黄斑中心凹视网膜厚度
AtorvastatinElderlyCataractMacular oedemaFovea center retinal thickness
《中外医学研究》 2024 (017)
25-28 / 4
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