中外医学研究2024，Vol.22Issue(18)：1-5,5.DOI:10.14033/j.cnki.cfmr.2024.18.001
替罗非班对IVT桥接EVT治疗急性前循环大血管闭塞性脑梗死患者预后的影响
Effect of Tirofiban on Prognosis of Patients with Acute Large Vessel Occlusion Stroke Treated with IVT Bridging EVT
陈静 1陈泽鹏 1江沛 1张强 2周敬华 2周华军2
作者信息
- 1. 宜都市人民医院 湖北 宜都 443300
- 2. 三峡大学第一临床医学院(宜昌市中心人民医院)
- 折叠
摘要
Abstract
Objective:To observe the effect of Tirofiban on the prognosis of patients with acute large vessel occlusion stroke(ALVOS)treated with intravenous thrombolysis(IVT)bridging endovascular therapy(EVT).Method:A total of 73 patients with ALVOS who admitted to Yidu People's Hospital from January 2021 to January 2023 were selected as the research objects,the patients were divided into the control group(36 cases)and the study group(37 cases)according to the random number table method.The control group was treated with IVT bridging EVT,and the study group was treated with Tirofiban on this basis,the number of thrombectomy and vascular recanalization rate,National Institutes of Health stroke scale(NIHSS)score,modified Rankin scale(mRS)score,neurological serological indicators[nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF),central nervous system specific protein β(S100β)],coagulation function[prothrombin time(PT),activated partial thromboplastin time(APTT),D-dimer(D-D)]and safety were compared between two groups.Result:The number of thrombectomy in the study group was less than that in the control group,and the difference was statistically significant(P<0.05);there was no significant difference in the vascular recanalization rate between two groups(P>0.05).The NIHSS score,mRS score,S100β and D-D levels in the study group after treatment were lower than those in the control group,NGF and BDNF levels were higher than those in the control group,PT and APTT were longer than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the symptomatic intracranial hemorrhage rate,various types of bleeding rate,recurrence rate and mortality between two groups(P>0.05).Conclusion:The addition of Tirofiban during IVT bridging EVT treatment can improve the neurological and coagulation function levels of ALVOS patients,with a good short-term prognosis.关键词
急性前循环大血管闭塞性脑梗死/替罗非班/静脉溶栓/桥接治疗/血管内治疗/预后Key words
Acute large vessel occlusion stroke/Tirofiban/Intravenous thrombolysis/Bridging therapy/Endovascular therapy/Prognosis引用本文复制引用
陈静,陈泽鹏,江沛,张强,周敬华,周华军..替罗非班对IVT桥接EVT治疗急性前循环大血管闭塞性脑梗死患者预后的影响[J].中外医学研究,2024,22(18):1-5,5.
