自拟栀豉温胆汤联合雷贝拉唑治疗反流性食管炎的效果OA
Effect of Self-made Zhichi Wendan Decoction Combined with Rabeprazole in the Treatment of Reflux Esophagitis
目的:观察自拟栀豉温胆汤联合雷贝拉唑治疗反流性食管炎(reflux esophagitis,RE)的效果.方法:选取2021 年 3 月—2022 年 12 月武威市凉州医院收治的 80 例RE患者,根据随机数表法将其分为A组(n=40)和B组(n=40).B组给予雷贝拉唑,A组在B组基础上给予自拟栀豉温胆汤.比较两组治疗前后中医症候积分、食管内镜检查评分、食管反流情况、血清指标,临床疗效,内镜疗效.结果:治疗后,两组中医症候积分均下降,A组中医症候积分低于B组,差异有统计学意义(P<0.05).治疗后,A组总有效率为 92.50%,明显高于B组的 75.00%,差异有统计学意义(P<0.05).治疗后,两组食管内镜检查评分均降低,A组食管内镜检查评分低于B组,差异有统计学意义(P<0.05).治疗后,A组内镜总有效率为 95.00%,高于B组的 67.50%,差异有统计学意义(P<0.05).治疗后,两组pH<4 反流次数、>5 min反流次数、pH<4时间、pH<4 时间百分比均降低,A组pH<4 反流次数、>5 min反流次数、pH<4 时间、pH<4 时间百分比均低于B组,差异有统计学意义(P<0.05).治疗后,两组白细胞介素-17(interleukin-17,IL-17)水平降低,胃动素(motilin,MTL)、胃泌素(gastrin,GAS)水平升高,A组IL-17水平低于B组,MTL、GAS水平均高于B组,差异有统计学意义(P<0.05).结论:自拟栀豉温胆汤联合雷贝拉唑治疗RE可有效减轻临床症状、炎症反应,改善食管反流情况.
Objective:To observe the effect of self-made Zhichi Wendan Decoction combined with Rabeprazole in the treatment of reflux esophagitis(RE).Method:A total of 80 RE patients who admitted to Liangzhou Hospital in Wuwei City from March 2021 to December 2022 were selected,they were divided into group A(n=40)and group B(n=40)according to the random number table method.Group B was given Rabeprazole,group A was given self-made Zhichi Wendan Decoction on the basis of group B.The traditional Chinese medicine syndrome score,esophageal endoscopy examination score,esophageal reflux condition,serum index before and after treatment,clinical efficacy and endoscopic efficacy were compared between two groups.Result:After treatment,the traditional Chinese medicine syndrome scores of two groups were decreased,and the traditional Chinese medicine syndrome score of group A was lower than that of group B,the differences were statistically significant(P<0.05).After treatment,the total effective rate of group A was 92.50%,which was significantly higher than 75.00%of group B,and the difference was statistically significant(P<0.05).After treatment,the scores of esophageal endoscopy examination in two groups were decreased,and the score of esophageal endoscopy examination in group A was lower than that in group B,the differences were statistically significant(P<0.05).After treatment,the total effective rate of endoscopy in group A was 95.00%,which was higher than 67.50%in group B,and the difference was statistically significant(P<0.05).After treatment,the pH<4 reflux times,>5 min reflux times,pH<4 time and pH<4 time percentage of two groups were decreased,and the pH<4 reflux times,>5 min reflux times,pH<4 time and pH<4 time percentage of group A were lower than those of group B,the differences were statistically significant(P<0.05).After treatment,the interleukin-17(IL-17)levels in two groups were decreased,motilin(MTL)and gastrin(GAS)levels were increased,the IL-17 level in group A was lower than those in group B,the MTL and GAS levels were higher than those in group B,the differences were statistically significant(P<0.05).Conclusion:Self-made Zhichi Wendan Decoction combined with Rabeprazole in the treatment of RE can effectively reduce clinical symptoms and inflammatory response,improve esophageal reflux condition.
李云;刘则鹏;滕飞;张丽娜
武威市凉州医院 甘肃 武威 733000甘肃省中医院
栀豉温胆汤反流性食管炎胃黏膜食管pH
Zhichi Wendan DecoctionReflux esophagitisGastric mucosaEsophageal pH
《中外医学研究》 2024 (018)
10-14 / 5
武威市市列科技计划项目(WW2101177)
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