摘要
Abstract
Objective:To observe the effect of modified Xiaoqinglong Decoction combined with Salmeterol Ticasone Powder Inhalant in the treatment of patients with bronchial asthma.Method:A total of 158 patients with bronchial asthma who admitted to Yongtai County Hospital of Traditional Chinese Medicine from January 2022 to June 2023 were selected as the study objects,they were divided into the western medicine group and the experimental group,79 cases in each group.The western medicine group was given Salmeterol Ticasone Powder Inhalant,and the experimental group was given modified Xiaoqinglong Decoction based on the western medicine group.The clinical efficacy,respiratory status,lung function before treatment and after 2 weeks of treatment,adverse reactions and recurrence were compared between two groups.Result:The total effective rate of the experimental group was higher than that of the western medicine group,and the difference was statistically significant(P<0.05).After 2 weeks of treatment,the pulmonary symptoms,activity ability and quality of life scores of two groups were decreased,and the pulmonary symptoms,activity ability and quality of life scores of the experimental group were lower than those of the western medicine group,the differences were statistically significant(P<0.05).After 2 weeks of treatment,the peak expiratory flow rate(PEF),forced vital capacity(FVC),maximum mid-expiratory flow rate(MMF)and forced expiratory volume in one second(FEV1)of two groups were increased,and the PEF,FVC,MMF and FEV1 of the experimental groups were all higher than those of the western medicine group,the differences were statistically significant(P<0.05).After 2 weeks of treatment,the levels of transforming growth faction-β1(TGF-β1),nerve growth factor(NGF)and thromboxane B2(TXB2)in two groups were decreased,and the levels of interferon-γ(IFN-γ)were increased,the levels of TGF-β1,NGF and TXB2 in the experimental groups were lower than those in the western medicine group,and the level of IFN-γ was higher than that in the western medicine group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).After 6 months of follow-up,the recurrence rate of the experimental group was lower than that of the western medicine group,and the difference was statistically significant(P<0.05).Conclusion:Modified Xiaoqinglong Decoction combined with Salmeterol Ticasone Powder Inhalant has significant effect in patients with bronchial asthma,significantly improving respiratory health impairment condition,lung function and cytokine levels,and reducing recurrence rate,with good safety.关键词
小青龙汤/沙美特罗替卡松粉吸入剂/支气管哮喘/肺功能Key words
Xiaoqinglong Decoction/Salmeterol Ticasone Powder Inhalant/Bronchial asthma/Lung function
