孙梓宜 1黄力 2姚魁武 3孙晓宁 4林建国 4王子涵 5张笑霄 4王擎擎 4段锦龙 4李春岩2
作者信息
- 1. 北京中医药大学研究生院(北京 100029)||中国中医科学院广安门医院心血管科(北京 100032)
- 2. 中日友好医院中西医结合心脏科(北京 100029)
- 3. 中国中医科学院广安门医院心血管科(北京 100032)||中国中医科学院学术管理处(北京 100700)
- 4. 中国中医科学院广安门医院心血管科(北京 100032)
- 5. 北京中医药大学研究生院(北京 100029)||中日友好医院中西医结合心脏科(北京 100029)
- 折叠
摘要
Abstract
Objective To explore the clinical differences among patients with chronic heart failure(CHF)with different Chinese medicine(CM)syndromes,and to identify the influencing factors of yang qi depletion and blood stasis syndrome.Methods Totally 179 patients with CHF was conducted in the Department of Integrative Cardiology,China-Japan Friendship Hospital,including 58 cases of qi deficiency and blood stasis syndrome(QBS),31 cases of qi and,yin deficiency and blood stasis syndrome(QYBS),and 90 cases of yang qi depletion and blood stasis syndrome(YBS).Demographic and sociological characteristics,New York Heart Association(NYHA)functional classification,and heart failure classifications[including heart failure with preserved ejection fraction(HFpEF),heart failure with mid-range ejection fraction(HFmrEF),heart failure with reduced ejection fraction(HFrEF)]were collected.Cardiac function-related indicators[including N-terminal pro-B-type natriuretic peptide(NT-proBNP),cardiac uhrasonography],laboratory test indicators(including routine blood tests,liver and kidney function,electrolytes)were detected.Quality of life in three domains(physical,emotional,and others)were assessed using the Minnesota Living with Heart Failure Questionnaire(MLHFQ).Differences among the CM syndromes were compared,and an unordered multinomial Logistic regression model was constructed to analyze the association between the influencing factors and QBS.Results Compared with the QBS,the YBS showed a higher NYHA class Ⅳpatients proportion,and MLHFQ scores in other domains(P＜0.05).The YBS showed fewer NYHA class Ⅱ and HFmrEF patients proportion,and higher MLHFQ physical and emotional domain scores,as well as total scores,than the QBS and QYBS(P＜0.05).Serum Ca2+,red blood cell(RBC)count,and hemoglobin(Hb)concentration were lower than those in the QYBS(P＜0.05).Compared with QBS,RBC,Hb,female gender,rare exercise,and NYHA class Ⅱ and Ⅲ were independent influencing factors for YBS.Conclusions QBS and QYBS are relatively stable stages of CHF progression.YBS represents a more severe stage.RBC,Hb,gender,exercise frequency,and NYHA classification can be used as auxiliary indices in the differentiation of YBS(Chinese Clinical Trial Registry,No.ChiCTR1900024482).关键词
慢性心力衰竭/中医证型/阳气亏虚血瘀证/Logistics回归分析Key words
chronic heart failure/Chinese medicine syndrome type/yang qi depletion and blood stasis syndrome/Logistics regression analysis
