中国中西医结合杂志2024，Vol.44Issue(7)：843-846,4.DOI:10.7661/j.cjim.20240114.100
升率汤对大鼠病态窦房结综合征模型窦房结电生理改变实验研究
Experimental Study on Electrophysiological Changes of Sick Sinus Syndrome Model Rats with Intervention of Shenglu Decoction
摘要
Abstract
Objective To study the effects of Shenglu Decoction(SLD)in electrophysiological function of sinoatrial node in sick sinus model rats,and explore the mechanism.Methods Forty sick sinus model rats were randomly divided into model group,SLD high,low dose and aminophylline groups,10 in each group.The other 10 rats were selected as sham group.The sham and model groups were given intragastric administration of physiological saline as 5 mL/d,the SLD high and low dose groups were given intragastric administration of SLD as 30.24 and 7.56 g·kg-1.The aminophylline group was given aminophylline as 80 mg·kg-1.Typical electrocardiograms were recorded before and after intervention.AA interval,sinus node recovery time(SNRT),corrected sinus node recovery time(CSNRT),and sinoatrial conduction time(SACT)were compared among different groups.Results Compared with the sham group,the AA interval,SNRT,CSNRT and SACT in the model group were significantly prolonged(P＜0.05).Compared with the model group,the AA interval,SNRT,CSNRT and SACT were significantly shortened in the SLD high dose and aminophylline groups after intervention(P＜0.05).Compared with the aminophylline group,the AA interval,SNRT and SACT were SLD high dose group after intervention(P＜0.05).Conclusion The high dose SLD could significantly improve the electrophysiological function of sinoatrial node in sick sinus model rats.关键词
升率汤/病态窦房结综合征/窦房结电生理功能/中药复方/氨茶碱Key words
Shenglu Decoction/sick sinus syndrome/electrophysiological function of sinus node/Chinese herbal compound/aminophylline引用本文复制引用
刘鹏,韩萍,柏晋梅..升率汤对大鼠病态窦房结综合征模型窦房结电生理改变实验研究[J].中国中西医结合杂志,2024,44(7):843-846,4.基金项目
山西省中医药研究院科研基金资助项目(No.201908) （No.201908）
