中国中西医结合杂志2024，Vol.44Issue(7)：868-873,6.DOI:10.7661/j.cjim.20240228.106
基于肠道菌群和胃肠激素探讨中医学脾胃论治男性生殖障碍性疾病生物学基础
Exploring Biological Basis of Chinese Medicine's Pi-Wei Theory in Treatment of Male Reproductive Disorders:Focus on Gut Microbiota and Gastrointestinal Hormones
摘要
Abstract
Objective Male reproductive disorders like infertility,erectile dysfunction,premature ejaculation,and prostatitis are significant influencing factors to declining fertility.In Chinese medicine(CM),the Shen is believed to store essence and govern reproduction,forming the foundation of congenital constitution.The Pi and Wei,responsible for the transformation and assimilation of nutrients from water and grains,are considered the foundation of the acquired constitution.This paper reviews relevant studies and suggests that disorders in male reproduction caused by Pi and Wei disharmony might be linked to disturbances in the gut microbiota and abnormalities in gastrointestinal hormones.The gut microbiota can affect serotonin through the blood-brain barrier,regulating ejaculation and erection.It also influences lipid metabolism through the blood-testis barrier,regulating penile vascular endothelium,mediating inflammatory responses,participating in androgen metabolism,and affecting testicular microcirculation.Different gastrointestinal hormones can mediate testicular inflammation and cell apoptosis,regulate testicular microcirculation,and modulate hormone secretion and spermatogenesis,thus having protective and damaging effects on testicular reproduction.The interaction between gut microbiota and gastrointestinal hormones could be the potential biological basis for CM's approach to treating male reproductive disorders through the theory of Pi and Wei.关键词
脾胃/肠道菌群/胃肠激素/生物学基础/男性生殖障碍性疾病/中西医结合Key words
Pi and Wei/gut microbiota/gastrointestinal hormones/biological basis/male reproductive disorders/integrative medicine引用本文复制引用
陈文康,赵家有..基于肠道菌群和胃肠激素探讨中医学脾胃论治男性生殖障碍性疾病生物学基础[J].中国中西医结合杂志,2024,44(7):868-873,6.基金项目
国家自然科学基金资助项目(No.82274337) （No.82274337）
首都卫生发展科研专项(No.首发2022-2-4271) （No.首发2022-2-4271）
中国中医科学院科技创新工程(No.CI2023C018YL,No.CI2021A02207) （No.CI2023C018YL,No.CI2021A02207）
中华中医药学会青年求实项目(No.2022-QNQSDEP-20) （No.2022-QNQSDEP-20）
