中医药学报2024，Vol.52Issue(8)：7-10,4.DOI:10.19664/j.cnki.1002-2392.240151
基于肠道菌群探讨艾滋病免疫重建不良"气虚湿阻"的病机与治法
Pathogenesis and Treatment of"Qi Deficiency and Dampness Obstruction"Syndrome of AIDS Immune Reconstitution Deficiency Based on Intestinal Flora
摘要
Abstract
The disorder of intestinal flora is closely related to the pathogenesis of AIDS immunological non-responders(INR).Combined with the theory of traditional Chinese medicine(TCM)and modern research,we believe that'qi deficiency and dampness obstruction'is the core pathogenesis of INR.The imbalance of intestinal flora is one of the biological basis of qi deficiency and dampness syndrome in TCM,which shares the similar pathogenesis of'qi deficiency and dampness obstruction'.Therefore,we can provide theoretical basis for the TCM treatment of INR from the perspectives of"qi deficiency and dampness obstruction"and gut microbiota.According to the treatment principle of TCM of reinforcing the healthy qi and eliminating the pathogenic factors,we have proposed a treatment method for INR that benefits qi and dispels dampness.Furthermore,by regulating the gut microbiota,we can promote immune reconstitution in INR patients,improving clinical symptoms.关键词
艾滋病/免疫重建不良/肠道菌群/气虚湿阻/病机Key words
AIDS/Immunological non-responders/Intestinal flora/Qi deficiency and dampness obstruction/Pathogenesis分类
医药卫生引用本文复制引用
陈守生,李鹏宇,陈莉华,何心怡,郇瑞博,赵泰龙,王丹妮,郭会军..基于肠道菌群探讨艾滋病免疫重建不良"气虚湿阻"的病机与治法[J].中医药学报,2024,52(8):7-10,4.基金项目
国家自然科学基金项目(82274474) （82274474）
中原领军人才(ZYY-CYU202012119) （ZYY-CYU202012119）
河南省科技攻关项目(232102311207,222102310570) （232102311207,222102310570）
河南省中医药科学研究专项(2022ZY1042) （2022ZY1042）
河南省特色骨干学科建设项目(STG-ZYXKY-2020031) （STG-ZYXKY-2020031）
河南省"双一流"创建学科中医学科学研究专项(HSRP-DF-CTCM-2023-6-03) （HSRP-DF-CTCM-2023-6-03）
