附子理中汤对非酒精性脂肪肝模型大鼠的保护作用及机制研究OACSTPCD
Protective Effect and Mechanism of Fuzi Lizhong Decoction on Nonalcoholic Fatty Liver Model Rats
目的:探究附子理中汤对非酒精性脂肪肝病(NAFLD)模型大鼠的保护作用及其可能的机制.方法:脂肪乳灌胃建立NAFLD模型大鼠,使用附子理中汤及阳性对照药物易善复治疗.HE和油红O染色观察肝脏和回肠病理损伤和脂肪沉积,全自动生化仪检测血清LDL-C、HDL-C、AST和ALT水平,qRT-PCR检测回肠组织的TNF-α和NF-κB p65 基因水平,ELISA法检测血清TNF-α水平.结果:与对照组相比,模型组大鼠肝脏和回肠发生病理损伤和脂肪沉积,…查看全部>>
Objective:To explore the protective effect of Fuzi Lizhong decoction(FLD)on non-alcoholic fatty liver disease(NAFLD)model rats and its possible mechanism.Methods:NAFLD model rats were established by gavage with fat milk,and treated with FLD and positive control drug polyene phosphatidylcholine capsule.HE and oil red O staining were used to observe the pathological damage and fat deposition of liver and ileum.The levels of serum LDL-C,HDL-C,AST and ALT were d…查看全部>>
杜念龙;杨家耀;徐丹;张书;时昭红
武汉市第一医院消化内科,湖北 武汉 430022武汉市第一医院消化内科,湖北 武汉 430022武汉市第一医院消化内科,湖北 武汉 430022武汉市第一医院消化内科,湖北 武汉 430022武汉市第一医院消化内科,湖北 武汉 430022
中医学
附子理中汤非酒精性脂肪肝病TNF-α/NF-κB信号通路
Fuzi Lizhong decoctionNonalcoholic fatty liver diseaseTNF-α/NF-κB signaling pathway
《中医药学报》 2024 (8)
17-21,5
武汉市卫健委医学科研项目(WZ21Q12)
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