中医药学报2024，Vol.52Issue(8)：40-46,7.DOI:10.19664/j.cnki.1002-2392.240156
共载吲哚菁绿与苦参碱温敏水凝胶的制备与表征
Preparation and Characterization of Indocyanine Green and Matrine Co-loaded Thermo Sensitive Hydrogel
摘要
Abstract
Objective:To prepare a kind of thermosensitive hydrogel that can be used for intratumoral injection.In this study,a thermosensitive hydrogel(MAT-ICG-gel)co-loaded with indocyanine green(ICG)and matrine(MAT)was designed using ICG as photosensitizer and poloxamer F127 and F68 as gel matrix.And the physicochemical properties of MAT-ICG-gel were characterized.Methods:The cold solution method was adopted to select the optimal preparation process of MAT-ICG-gel through single factor experiment,with the gelation temperature and gelation time as the evaluation indexes.The morphology,rheological properties,photothermal conversion properties,dissolution properties,in vitro release and preliminary stability of MAT-ICG-gel prepared by using the optimal preparation technology were investigated.Results:The optimal prescription composition of MAT-ICG-GEL was F127∶F68=20∶3.5,MAT∶ICG=10∶1.The optimal formulation was used to prepare MAT-ICG gel,with a gelation temperature of(37.3±0.2)℃,a gelation time of(181±3.6)s,and good stability within 7 days.The viscosity of MAT-ICG-gel increased sharply from 37℃and became stable at 42℃.MAT-ICG-gel exhibited good photothermal conversion performance under 808 nm of laser irradiation.When compared to 37℃,the dissolution rate and drug release rate of MAT-ICG-gel at 42℃were both more slowly.Conclusion:The preparation process of MAT-ICG-gel is simple and feasible.MAT-ICG-gel has good photothermal conversion performance,biodegradability and temperature-dependent sustained drug release characteristics.This study can provide new ideas and theoretical basis for the development of new dosage forms of matrine combined with photothermal therapy.关键词
苦参碱/吲哚菁绿/温敏水凝胶/光热治疗Key words
Matrine/Indocyanine green/Thermosensitive hydrogel/Photothermal therapy分类
医药卫生引用本文复制引用
王子昂,李一菁,直炜炜,黄菲,段萌媛,陈丽娟,祝侠丽..共载吲哚菁绿与苦参碱温敏水凝胶的制备与表征[J].中医药学报,2024,52(8):40-46,7.基金项目
国家自然科学基金项目(81803740) （81803740）
河南省高等学校重点科研项目(23A360007) （23A360007）
