首页|期刊导航|Bone Research|Kdm6a-CNN1 axis orchestrates epigenetic control of traumainduced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair

Kdm6a-CNN1 axis orchestrates epigenetic control of traumainduced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair

Chengjun Li Tian Qin Jinyun Zhao Yuxin Jin Yiming Qin Rundong He Tianding Wu Chunyue Duan Liyuan Jiang Feifei Yuan Hongbin Lu Yong Cao Jianzhong Hu

Bone Research2024，Vol.12Issue(2)：P.314-333,20.

Bone Research2024，Vol.12Issue(2)：P.314-333,20.DOI:10.1038/s41413-024-00323-x

Kdm6a-CNN1 axis orchestrates epigenetic control of traumainduced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair

Chengjun Li ¹Tian Qin ²Jinyun Zhao ²Yuxin Jin ²Yiming Qin ²Rundong He ²Tianding Wu ²Chunyue Duan ²Liyuan Jiang ²Feifei Yuan ²Hongbin Lu ¹Yong Cao ²Jianzhong Hu²

作者信息

1. Department of Sports Medicine,Xiangya Hospital,Central South University,Xiangya Road 87,Changsha 410008,China Key Laboratory of Organ Injury,Aging and Regenerative Medicine of Hunan Province,Xiangya Road 87,Changsha 410008,China National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Xiangya Road 87,Changsha 410008,China
2. Key Laboratory of Organ Injury,Aging and Regenerative Medicine of Hunan Province,Xiangya Road 87,Changsha 410008,China National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Xiangya Road 87,Changsha 410008,China Department of Spine Surgery and Orthopaedics,Xiangya Hospital,Central South University,Xiangya Road 87,Changsha 410008,China
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摘要

关键词

inflammation/epigenetic/neurological

分类

医药卫生

引用本文复制引用

Chengjun Li,Tian Qin,Jinyun Zhao,Yuxin Jin,Yiming Qin,Rundong He,Tianding Wu,Chunyue Duan,Liyuan Jiang,Feifei Yuan,Hongbin Lu,Yong Cao,Jianzhong Hu..Kdm6a-CNN1 axis orchestrates epigenetic control of traumainduced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair[J].Bone Research,2024,12(2):P.314-333,20.

基金项目

funded by National Natural Science Foundation of China(grant 82030071 and 82272495) （grant 82030071 and 82272495）

Natural Science Foundation of Hunan Province(grant 2020JJ5930 and 2020JJ4874) （grant 2020JJ5930 and 2020JJ4874）

the Science and Technology Major Project of Changsha(No.kh2103008). （No.kh2103008）

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