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首页|期刊导航|Bone Research|The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi

Bone Research2024，Vol.12Issue(2)：P.289-301,13.
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Bone Research2024，Vol.12Issue(2)：P.289-301,13.DOI:10.1038/s41413-024-00320-0

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

Heeseog Kang 1Amy L.Strong 2Yuxiao Sun 1Lei Guo 3Conan Juan 1Alec C.Bancroft 1Ji Hae Choi 1Chase A.Pagani 1Aysel A.Fernandes 4Michael Woodard 1Juhoon Lee 5Sowmya Ramesh 6Aaron W.James 6David Hudson 4Kevin N.Dalby 5Lin Xu 3Robert J.Tower 1Benjamin Levi1

作者信息

  • 1. Center for Organogenesis,Regeneration and Trauma,Department of Surgery,University of Texas Southwestern,Dallas,TX 75390,USA
  • 2. Section of Plastic Surgery,Department of Surgery,University of Michigan,Ann Arbor,MI 48109,USA
  • 3. Quantitative Biomedical Research Center,Peter O’Donnell Jr.School of Public Health,University of Texas Southwestern,Dallas,TX 75390,USA
  • 4. Department of Orthopedics and Sports Medicine,University of Washington,Seattle,WA 98195,USA
  • 5. Division of Chemical Biology and Medicinal Chemistry,College of Pharmacy,University of Texas at Austin,Austin,TX 78712,USA
  • 6. Department of Pathology,Johns Hopkins University,Baltimore,MD 21218,USA
  • 折叠

摘要

关键词

metabolism/skeletal/aberrant

分类

医药卫生

引用本文复制引用

Heeseog Kang,Amy L.Strong,Yuxiao Sun,Lei Guo,Conan Juan,Alec C.Bancroft,Ji Hae Choi,Chase A.Pagani,Aysel A.Fernandes,Michael Woodard,Juhoon Lee,Sowmya Ramesh,Aaron W.James,David Hudson,Kevin N.Dalby,Lin Xu,Robert J.Tower,Benjamin Levi..The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair[J].Bone Research,2024,12(2):P.289-301,13.

基金项目

The authors thank Dave Primm,Sneha Korlakunta,and Metabolomics Facility(Children’s Research Institute,UTSW)for their kind assistance and technical support with manuscript preparation.B.L.supported by NIH R01 AR078324 and R01 AR071379. （Children’s Research Institute,UTSW）

Bone Research

OAMEDLINE

2095-4700

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