Microgels for Cell Delivery in Tissue Engineering and Regenerative MedicineOACSTPCDEI
Microgels prepared from natural or synthetic hydrogel materials have aroused extensive attention as multifunctional cells or drug carriers,that are promising for tissue engineering and regenerative medicine.Microgels can also be aggregated into microporous scaffolds,promoting cell infiltration and proliferation for tissue repair.This review gives an overview of recent developments in the fabrication techniques and applications of microgels.A series of conventional and novel strategies including emulsification,microfluidic,lithography,electrospray,centrifugation,gas-shearing,three-dimensional bioprinting,etc.are discussed in depth.The characteristics and applications of microgels and microgel-based scaffolds for cell culture and delivery are elaborated with an emphasis on the advantages of these carriers in cell therapy.Additionally,we expound on the ongoing and foreseeable applications and current limitations of microgels and their aggregate in the field of biomedical engineering.Through stimulating innovative ideas,the present review paves new avenues for expanding the application of microgels in cell delivery techniques.
Leyan Xuan;Yingying Hou;Lu Liang;Jialin Wu;Kai Fan;Liming Lian;Jianhua Qiu;Yingling Miao;Hossein Ravanbakhsh;Mingen Xu;Guosheng Tang;
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology,the NMPA and State Key Laboratory of Respiratory Disease,School of Pharmaceutical Sciences and the Fifth Affiliated Hospital,Guangzhou Medical University,Guangzhou 511436,People''s Republic of ChinaSchool of Automation,Hangzhou Dianzi University,Hangzhou 310018,People''s Republic of ChinaWallace H.Coulter Department of Biomedical Engineering,Georgia Institute of Technology,Atlanta,GA 30332,USADepartment of Biomedical Engineering,The University of Akron,Akron,OH 44325,USA
基础医学
MicrogelsCell deliveryScaffolds3D bioprintingSingle-cell microgels
《Nano-Micro Letters》 2024 (010)
P.576-617 / 42
supported by the National Key Research and Development Program of China(No.2022YFA1104600);the National Natural Science Foundation of China(NSFC)Program(Nos.32201183,31927801,32101105);the Science and Technology Program of Guangzhou(SL2022A04J00774).
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