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维生素A与孤独症谱系障碍相关性的研究进展OA

Research Progress on the Correlation between Vitamin A and Autism Spectrum Disorder

中文摘要英文摘要

孤独症谱系障碍(autism spectrum disorder,ASD)是一种具有高度遗传性的神经发育障碍性疾病,其病因和致病机制尚未明确.维生素A是一种维持人体正常代谢和机能所必需的脂溶性维生素,参与了大脑的发育过程和神经系统功能调控.新近研究显示维生素A水平的变化可引起神经和行为等方面的障碍,继而产生ASD样症状.维生素A与ASD的发生发展密切相关,缺乏维生素A会加重社会交流障碍、刻板行为等ASD核心症状,补充维生素A能部分改善其症状.故而就维生素A与ASD的关系及其相关机制和对ASD的治疗作用等方面进行综述,为ASD的诊断和干预提供依据.

Autism spectrum disorder(ASD)is a highly inherited neurodevelopmental disorder,and its etiology and pathogenesis are still unclear.Vi-tamin A is a fat-soluble vitamin necessary for maintaining normal metabolism and function of the human body.It is involved in the development of the brain and the regulation of nervous system function.Recent studies have shown that changes in vitamin A levels can cause neurological and be-havioral disorders,and then produce ASD-like symptoms.Vitamin A is closely related to the occurrence and development of ASD.Vitamin A is closely related to the occurrence and development of ASD.Vitamin A deficiency can aggravate the core symptoms of ASD such as social communica-tion disorders and stereotyped behaviors,and vitamin A supplementation can partially improve the symptoms.Therefore,this article reviews the rela-tionship between vitamin A and ASD,its related mechanisms,and its therapeutic effects on ASD,so as to provide a basis for the diagnosis and inter-vention of ASD.

陈冰;李坤;姜志梅

佳木斯大学附属第三医院,黑龙江佳木斯 154002

临床医学

孤独症谱系障碍维生素A相关性

autism spectrum disorderVitamin Arelevance

《中医康复》 2024 (009)

49-53 / 5

佳木斯大学优秀学科团队项目(JDXKTD-2019006)

10.19787/j.issn.2097-3128.2024.09.010

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