康复学报2024，Vol.34Issue(4)：402-410,9.DOI:10.3724/SP.J.1329.2024.04014
运动康复训练调节线粒体损伤对慢性阻塞性肺疾病骨骼肌功能障碍的影响
Effect of Exercise Rehabilitation Training Regulating Mitochondrial Damage on Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease
摘要
Abstract
Chronic obstructive pulmonary disease(COPD)is a heterogeneous chronic respiratory condition,and skeletal mus-cle dysfunction is one of its common complications,mainly clinically manifested as decreased muscle strength and endurance,al-tered muscle fiber type and decreased skeletal muscle mass.Mitochondrial damage is one of the key factors causing skeletal muscle dysfunction.Mitochondria not only provide energy for skeletal muscle,but also participate in reactive oxygen species(ROS)produc-tion,autophagy and protein turnover,which is of great significance to maintain the normal function of skeletal muscle.This study elucidated the mitochondrial changes in skeletal muscle dysfunction in patients with COPD,the mechanism of mitochondrial dam-age in skeletal muscle dysfunction in patients with COPD,and the potential effects of exercise rehabilitation training on mitochondri-al damage in skeletal muscle in patients with COPD,in order to further clarify the relationship between mitochondria and skeletal muscle function,and to provide a reference for optimizing the exercise rehabilitation program for skeletal muscle dysfunction in COPD.The mitochondrial changes of skeletal muscle dysfunction in COPD mainly include impairment of the mitochondrial respira-tory chain,a surge in mitochondrial autophagy,and a decreased in mitochondrial biogenesis.The mechanisms underlying mitochon-drial damage of skeletal muscle dysfunction in COPD mainly include increasing skeletal muscle degradation,decreasing of skeletal muscle production and interfering with skeletal muscle differentiation.The potential effects of exercise rehabilitation training regulat-ing mitochondrial damage in COPD skeletal muscle mainly include repairing the respiratory chain of skeletal muscle mitochondria in COPD patients,regulating mitophagy of skeletal muscle mitochondria,and promote the mitochondrial biogenesis of skeletal mus-cle in patients with COPD.Future research still needs to explore the key role of mitochondria in maintaining the normal functional structure of skeletal muscle,the mechanism of COPD skeletal muscle dysfunction,and the specific mechanism of exercise rehabilita-tion training in regulating mitochondrial damage to improve COPD skeletal muscle dysfunction,so as to provide a reference for exer-cise rehabilitation training in COPD skeletal muscle dysfunction.关键词
慢性阻塞性肺疾病/骨骼肌功能障碍/线粒体损伤/线粒体自噬/运动康复训练Key words
chronic obstructive pulmonary disease/skeletal muscle dysfunction/mitochondrial damage/mitophagy/exercise rehabilitation training引用本文复制引用
李抗夏,王颖祺,陈采陶,宋艳霞,吴卫兵,李健..运动康复训练调节线粒体损伤对慢性阻塞性肺疾病骨骼肌功能障碍的影响[J].康复学报,2024,34(4):402-410,9.基金项目
国家自然科学基金项目(82205276) （82205276）
上海市扬帆计划项目(22YF1434100) （22YF1434100）
海军军医大学第一附属医院基础研究专项(2021JCQN07) （2021JCQN07）
