Highly-Sensitive Polymer Optical Fiber SPR Sensor for Fast ImmunoassayOAEI
Highly-Sensitive Polymer Optical Fiber SPR Sensor for Fast Immunoassay
A new type of human immunoglobulin G(IgG)sensors based on the surface plasmon resonance(SPR)in the low refractive index(RI)plastic optical fiber(POF)and an antibody immobilization method is presented.A 50-nm-thick gold film was formed on the polished D-shaped fiber surface by magnetron sputtering.The RI response of the POF sensor is 30 049.61 nm/RIU,which is 26.5 times higher than that of single mode fiber(SMF)SPR sensors.The proposed SPR biosensor can be developed by simple and rapid modification of the gold film with 11-mercapto undecanoic acid(MUA).Upon immobilization of the goat anti-human IgG antibody,the resonance wavelength shifts by 11.2 nm.The sensor can be used to specifically detect and quantify the human IgG at concentrations down to 245.4 ng/mL with the sensitivity of 1.327 7 nm per μg/mL,which offers an enhancement of 12.5-fold compared to that of the conventional SMF based SPR sensors.The proposed device may find the potential applications in the case of use at the point of care.
Ying WANG;Xing RAO;Xun WU;George Y.CHEN;Changrui LIAO;Mateusz Jakub SMIETANA;Yiping WANG
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education/Guangdong Province,College of Physics and Optoelectronic Engineering,Shenzhen University,Shenzhen 518060,China||Shenzhen Key Laboratory of Photonic Devices and Sensing Systems for Internet of Things,Guangdong and Hong Kong Joint Research Centre for Optical Fibre Sensors,Shenzhen University,Shenzhen 518060,ChinaDivision of Microsystem & Electronic Materials Technology,Institute of Microelectronics & Optoelectronics,Warsaw University of Technology,Koszykowa 75,00-662 Warsaw,Poland
Optical fiber biosensorsurface plasmon resonanceantibody immobilizationside-polished fiberplastic optical fiber
《光子传感器（英文版）》 2024 (004)
20-30 / 11
This work was supported by the National Natural Science Foundation of China(Grant No.62275172);Natural Science Foundation of Guangdong Province(Grant No.2023A1515012893);Science,Technology,and Innovation Commission of Shenzhen Municipality(Grant Nos.KQTD20221101093605019 and JCYJ20220818095615034);Shenzhen Key Laboratory of Ultrafast Laser Micro/Nano Manufacturing(Grant No.ZDSYS20220606100405013);Research Start-Up Fund for High-End Talent at Shenzhen University.
评论