广州医药2024，Vol.55Issue(7)：770-775,6.DOI:10.3969/j.issn.1000-8535.2024.07.012
分析不同高血压分级血压变异性与空腹甘油三酯血糖指数及内皮功能的相关性
Analysis of the correlation between blood pressure variability in different hypertension grades and fasting triglyceride blood glucose index and endothelial function
高辉 1曹玉枝 1陈建都 1孙婷婷 1黄一玲1
作者信息
- 1. 天津市第一医院内一科(天津 300232)
- 折叠
摘要
Abstract
Objective To explore the correlation between blood pressure variability and fasting triglyceride blood glucose index and endothelial function in different hypertension grades.Methods A total of 150 hypertensive patients admitted to our hospital from October 2020 to October 2023 were selected as study participants.Patients were classified into group level 1(n=50),with systolic blood pressure 140～159 mmHg and/or diastolic blood pressure 90～99 mmHg,group level 2(n=60),with systolic blood pressure 160～179 mmHg and/or diastolic blood pressure 100～109 mmHg,and group level 3(n=40),with systolic blood pressure≥180 mmHg and/or diastolic blood pressure≥110 mmHg.SBPwSD and DBPwSD of all patients were measured to assess their blood pressure variability.Fasting blood glucose and fasting triglyceride levels were measured to calculate TyG.MDA,NO,ET-1 and SOD were used to evaluate endothelial function.The correlation between blood pressure variability and glycemic index and endothelial function was analysed using Spearman correlation analysis.Results The DBPwSD and SBPwSD of the group level 1 were significantly lower than those of the groups level 2 and 3(P＜0.05).The fasting blood glucose,fasting triglycerides and TyG in the group level 1 were significantly lower than those in the groups level 2 and 3(P＜0.05).MDA and ET-1 values in the group level 1 were significantly lower than in the groups level 2 and 3,while NO and SOD values in the group level 1 were significantly higher than those in the other two groups(P＜0.05).DBPwSD and SBPwSD did not correlate significantly with fasting blood glucose and fasting triglycerides(P＞0.05),while DBPwSD and SBPwSD correlated negatively with NO and SOD values and correlated positively with TyG,MDA and ET-1(P＜0.05).Conclusions There are significant differences in blood pressure variability,TyG,and endothelial function among hypertensive patients with different grades,and there is a significant correlation between blood pressure variability and TyG and endothelial function in hypertensive patients.关键词
高血压/血压变异性/空腹甘油三酯血糖指数/血管内皮功能/相关性/高血压分级Key words
hypertension/blood pressure variability/fasting triglyceride blood glucose index/vascular endothelial function/correlation/hypertension classification引用本文复制引用
高辉,曹玉枝,陈建都,孙婷婷,黄一玲..分析不同高血压分级血压变异性与空腹甘油三酯血糖指数及内皮功能的相关性[J].广州医药,2024,55(7):770-775,6.
