中国实用神经疾病杂志2024，Vol.27Issue(8)：925-930,6.DOI:10.12083/SYSJ.231384
两样本孟德尔随机化分析循环代谢产物与吉兰-巴雷综合征的因果关系
Analysis of the causal relationship between circulating metabolites and Guillain-Barré syndrome by two sample Mendelian randomization
摘要
Abstract
Objective To investigate the causal relationship between 417 circulating metabolites and the risk of Guillain-Barré syndrome(GBS)using two sample Mendelian randomization(MR)analysis method.Methods Three genome-wide association studies(GWAS)of circulating metabolites were obtained through the MRC IEU OpenGWAS project,namely"met-a","met-c",and"met-d".The data on single nucleotide polymorphism sites(SNPs)related to GBS was sourced from the FinnGen Consortia database,with the phenotype code"finn-b-G6_GUILBAR".Genetic variation data(SNPs)closely related to circulating metabolites from GWAS was used as instrumental variables(IVs)and a two-sample MR analysis with GBS GWAS data from Finland was conducted.The inverse variance weighted(IVW)method of the random effects model was mainly used,and the results were evaluated based on the odds ratio(OR)and 95%CI of the effect indicators.The leave-one-out method,heterogeneity test,and horizontal gene pleiotropy test were used to verify the stability and reliability of the results.Results There was suggestive evidence for a causal relationship between 5 circulating metabolites and GBS.Among them,the circulating level of creatinine(OR=2.924,95%CI:1.194-7.163,P=0.019),glutamine(OR=1.902,95%CI:1.007-3.592,P=0.048)and isovaleryl carnitine(OR=140.767,95%CI:3.510-5 645.336,P=0.009)were associated with a higher risk of GBS.On the contrary,genetic predicted the circulating level of glucose(OR=0.308,95%CI:0.010-0.981,P=0.046)and X-11491(OR=0.069,95%CI:0.007-0.707,P=0.024)were negatively correlated with the risk of GBS.Conclusion Creatinine,glutamine,isovaleryl carnitine,glucose and X-11491 may have causal relationships with GBS.关键词
吉兰-巴雷综合征/循环代谢产物/单核苷酸多态性位点/工具变量/孟德尔随机化/因果关系Key words
Guillain-Barré syndrome/Circulating metabolites/Single nucleotide polymorphism sites/Instrumental variables/Mendelian randomization/Causal effect分类
临床医学引用本文复制引用
宁萍萍,杨颖,牟欣..两样本孟德尔随机化分析循环代谢产物与吉兰-巴雷综合征的因果关系[J].中国实用神经疾病杂志,2024,27(8):925-930,6.基金项目
中国博士后科学基金第73批面上资助项目(编号:2023M732162) （编号:2023M732162）
2023年陕西省博士后科研项目(编号:2023BSHGZZHQYXMZZ33) （编号:2023BSHGZZHQYXMZZ33）
陕西省自然科学基础研究计划(编号:2024JC-YBQN-0822) （编号:2024JC-YBQN-0822）
中央高校基本科研业务费专项资金资助项目(编号:xzy012024125) （编号:xzy012024125）
