中国实用神经疾病杂志2024，Vol.27Issue(8)：931-935,5.DOI:10.12083/SYSJ.231856
微小RNA-34a沉默信息调节因子1与急性缺血性脑卒中患者侧支循环的关系
Relationship between miR-34a,sirt1 and collateral circulation in patients with acute ischemic stroke
摘要
Abstract
Objective To analyze the predictive value of microRNA-34a(miR-34a)and silent information regulator 1(sirt1)in the establishment of collateral circulation in patients with acute ischemic stroke.Methods Eighty-two patients with acute ischemic stroke were enrolled as the research objects,and the basic data such as NIHSS score of the patients were recorded,and were divided into the poor collateral circulation group(32 cases)and the good collateral circulation group(50 cases)according to digital subtraction angiography 5 days after admission.Enzyme-linked immunosorbent assay(ELISA)was used to detect serum sirt1 level,and real-time fluorescent quantitative PCR was used to detect serum miR-34a level.Pearson method was used to analyze the correlation between sirt1,miR-34a and general data.ROC curve was used to evaluate the predictive value of sirt1 and miR-34a on the establishment of collateral circulation.Logistic regression was used to analyze the factors affecting the establishment of collateral circulation.Results Hypertension(65.63%),hypercholesterolemia(28.13%),NIHSS score at admission((16.57±3.30)points),cerebral infarction volume((11.02±3.27)cm3),and miR-34a(1.58±0.42)in the poor collateral circulation group were higher than those in the good collateral circulation group(40.00%,8.00%,(10.14±3.01)points,(6.39±2.01)cm3,1.00±0.23,respectively),while sirt1((5.09±1.57)μg/L)was lower than that in the good collateral circulation group((7.63±1.53)μg/L,P<0.05).The levels of miR-34a and sirt1 were negatively correlated in acute ischemic stroke patients with poor collateral circulation(r=-0.521,-0.529,P<0.05),the hypertension,hypercholesterolemia,NIHSS score at admission,and cerebral infarction volume were positively correlated with miR-34a(P<0.05),and were negatively correlated with sirt1(P<0.05).The area under the curve(AUC)of miR-34a,sirt1,and the combination for predicting poor establishment of collateral circulation in patients with acute ischemic stroke was 0.882,0.901,and 0.935,respectively.miR-34a and sirt1 were independent factors influencing the establishment of collateral circulation in patients with acute ischemic stroke(P<0.05).The proportion of patients with poor prognosis in the group with poor collateral circulation was higher than that in the group with good collateral circulation(P<0.05).Conclusion miR-34a and sirt1 have certain predictive effects on the establishment of collateral circulation in patients with acute ischemic stroke.关键词
急性缺血性脑卒中/侧支循环/微小RNA-34a/沉默信息调节因子1Key words
Acute ischemic stroke/Collateral circulation/microRNA-34a/Silent information regulator 1分类
医药卫生引用本文复制引用
张敏,王敏,司君增..微小RNA-34a沉默信息调节因子1与急性缺血性脑卒中患者侧支循环的关系[J].中国实用神经疾病杂志,2024,27(8):931-935,5.基金项目
济南市卫生健康委员会科技计划项目(编号:2021-2-18) （编号:2021-2-18）
