可降解镁基金属引导骨再生膜的研究现状与展望OA北大核心CSTPCDMEDLINE
Research status and prospects of biodegradable magnesium-based metal guided bone regeneration membranes
可降解镁基金属引导骨再生(GBR)膜具有良好的机械性能、生物降解性和生物促成骨性能,是治疗颌面部骨缺损的理想植入物.本文对镁基金属引导骨再生膜的现状和未来的研究趋势进行阐述.首先介绍了镁基金属的研究历史及应用领域,随后从镁基金属GBR膜的机械性能、生物相容性和促成骨性能及其机制方面介绍了镁基金属制备GBR膜的应用优势,最后对当前镁基金属GBR膜的局限性及在口腔医学中的应用和展望进行介绍.镁基金属GBR膜在基础和转化研究方面都取得了重要的进展,为治疗口腔颌面部的骨缺损奠定了重要的基础.
Biodegradable magnesium-based metal guided bone regeneration(GBR)membranes possess excellent me-chanical properties,biodegradability,and osteopromotive capabilities,making them ideal implants for the treatment of maxillofacial bone defects.This review summarizes the current status and future research trends related to magnesium-based GBR membranes.First,the research history and application fields of magnesium-based metals are introduced,and the advantages of the use of magnesium-based materials for GBR membranes,including their mechanical properties,bio-compatibility,osteopromotive performance,and underlying mechanisms are discussed.Finally,this review addresses the current limitations of magnesium-based GBR membranes and their applications and prospects in the field of dentistry.In conclusion,considerable advancements have been in fun-damental and translational research on magnesium-based GBR membranes,which lays a crucial foundation for the treatment of maxillofacial bone defects.
陈良伟;韩建民;郭传瑸
北京大学口腔医学院·口腔医院口腔颌面外科,北京 100081||国家口腔医学中心·国家口腔疾病临床医学研究中心·口腔生物材料和数字诊疗装备国家工程研究中心,北京 100081国家口腔医学中心·国家口腔疾病临床医学研究中心·口腔生物材料和数字诊疗装备国家工程研究中心,北京 100081||北京大学口腔医学院·中心实验室,北京 100081
基础医学
镁基金属引导骨再生膜降解骨再生临床转化
magnesium-based metalguided bone regeneration membranedegradationbone regenera-tionclinical translation
《华西口腔医学杂志》 2024 (004)
415-425 / 11
National Key Research and Development Program of China(2021YFC2400703);National Natural Sci-ence Foundation of China(52171234);Beijing Municipal Science and Technology Project(Z211100002921066);Peking University National Clinical Key Specialty Translation Support Project(PKUSSNKP-T202104) 国家重点研发计划(2021YFC2400703);国家自然科学基金(52171234);北京市科技计划(Z211100002921066);北京大学口腔医院国家临床重点专科科技成果转化支持项目(PKUSS-NKP-T202104)
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