脑白质病变患者血压变异性、脑白质血流量与认知功能障碍的关系OACSTPCD
Relationship between blood pressure variability,white matter blood flow and cognitive dysfunction in patients with white matter lesions
目的 探索血压变异性(BPV)、脑白质病变(WMLs)、局部脑血流量(rCBF)与认知功能之间的关系.方法 采用Fazekas量表评定WMLs程度,采用颅脑灌注成像检测rCBF,采用24h动态血压监测计算血压变异系数(CV)来测量BPV,采用蒙特利尔认知评估量表(MoCA)评估认知功能.结果 多因素Logistics回归分析显示,与24h收缩压(SBP)CV Q1 组相比,Q3 组及Q4 组平均脑白质CBF(MWCBF)显著降低(OR=5.63,…查看全部>>
Objective To explore the relationship between blood pressure variability(BPV),white matter lesions(WMLs),regional cerebral blood flow(rCBF)and cognitive function.Methods The degree of WMLs was assessed by Fazekas scale.rCBF was detected by brain perfusion imaging.Twenty-four hour ambulatory blood pressure monitoring was used to calculate the blood pressure coefficient of variation(CV)to measure BPV.Cognitive function was assessed by Montreal cognitive assess…查看全部>>
谭沙一君;刘逊;尹瑾;张俊霞;何明利
222061 南京医科大学连云港临床医学院徐州医科大学附属连云港医院神经内科徐州医科大学附属连云港医院神经内科徐州医科大学附属连云港医院神经内科222061 南京医科大学连云港临床医学院
临床医学
高血压血压变异性脑白质病变认知功能障碍脑血流量
high blood pressureblood pressure variabilitywhite matter lesionscognitive dysfunctioncerebral blood flow
《临床神经病学杂志》 2024 (4)
241-249,9
国家自然科学基金项目(81970348)
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